Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT).

NCT ID: NCT03661463

Last Updated: 2019-10-28

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-10-24
• Study Completion Date: 2019-12-31

Brief Summary

Does Aspirin reduce inflammation in the walls of unruptured brain aneurysms?

Brain aneurysms are balloon-like outpouchings of a blood vessel resulting from a weakness in the vessel wall. They generally cause no symptoms, but can burst and cause a bleed in the brain, resulting in death or disability. Aneurysms occur in 1 in 30 people, but rarely burst, with 1 in 10,000 people having a brain bleed.

Ideally, aneurysms would be treated before they burst to prevent bleeding in the brain. The two ways of treating aneurysms currently are both risky and invasive, and no medications have been shown to reduce the risk of aneurysms bursting.

Aspirin is one of the most common medications, used worldwide to treat pain, fever and inflammation, and for the prevention of strokes and heart attacks. Its anti-inflammatory properties may be beneficial for patients with aneurysms. We know that the walls of burst aneurysms and aneurysms that are about to burst, are more inflamed than those that do not burst. Therefore, a drug that reduces inflammation may reduce the risk of an aneurysm bursting.

We have designed this study to test whether there is a measurable reduction in inflammation in walls of brain aneurysms.

In this study, participants known to have an aneurysm that is not planned for treatment and has not yet burst, take aspirin daily for three months, and have an MRI scan before and after to look for a reduction in inflammation.

If this study is successful it would be the first step towards developing the first medication to help treat patients with aneurysms, representing a huge advance for the 2.1 million people in the UK with this condition.

Detailed Description

The Unruptured Intracranial Aneurysm Aspirin Trial (UIAAT) is a single centre, randomised, single blind, open label trial of 300mg aspirin daily versus no treatment for 3 months. 58 patients with an intracranial aneurysm diagnosed on imaging will be recruited - potential participants will be approached by their consultant neurosurgeon or a member of their direct clinical care team.

Patient interviews will take place at Wessex Neurological Centre to coincide wherever possible with standard appointments. Participants will be screened for eligibility and consented during this interview. Following consent, baseline data will be taken to include participants' baseline characteristics, other medications, and comorbidities.

The patients will then undergo a baseline MRI including VWI imaging, and then be randomised to either the 'aspirin 300mg daily' or 'no treatment' arms.

All participants will then be called by a member of the trial team between days 7 and 21 after being commenced in either arm of the trial, to review any issues with taking the medication if they are on that arm, whether they are using their drug diary, and to check for any adverse reactions or events.

Following three months of their allocated treatment, patients will undergo a second, identical MRI scan, to assess whether there is any reduction in the inflammation in the vessel walls of the aneurysms. Patients will be reviewed at this time with their drug dairy, for drug reconciliation and recording of any adverse events. This will be the end of their participation in the trial.

The study topic and design was discussed at a meeting to set research priorities advertised via the Wessex Subarachnoid Haemorrhage group that was convened by a consultant neurosurgeon and a subarachnoid haemorrhage specialist nurse with patients with unruptured and ruptured aneurysms and their carers. At this meeting the investigators clearly identified that it would be beneficial for more research into medical treatments for unruptured aneurysms and felt that with the evidence that the group would be happy to undergo the main two items required for participation in the study - treatment with aspirin and increased scanning frequency and were very supportive of the study design. Indeed the group saw the additional scanning as a strong attraction to participating in the study.

Conditions

Intracranial Aneurysm; Inflammation

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Aspirin

Aspirin (Acetylsalicylic Acid \[ASA\]) tablets, 300mg once a day, for 90 days.

Group Type: EXPERIMENTAL

Aspirin

Intervention Type: DRUG

Drug

No Treatment

No medical treatment

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Aspirin

Drug

Intervention Type: DRUG

Other Intervention Names

acetylsalicylic acid

Eligibility Criteria

Inclusion Criteria

Participants who will be eligible for inclusion in the study will:

• Have a saccular unruptured intracranial aneurysm identified on imaging (CT, MRI or DSA),
• Aneurysm ≥5mm
• Be aged 18 or over
• Male or female
• Capable of giving written informed consent
• Females of childbearing potential must have a negative pregnancy test. Patients of childbearing potential must agree to use an effective birth control method to avoid pregnancy for the duration of the study.

Exclusion Criteria

Participants will be ineligible for inclusion in the study if they have any of the following:-

• aneurysms smaller than 5mm in size.
• Aneurysm types of the following nature:

• Fusiform aneurysms
• Dissecting aneurysm
• Traumatic aneurysms
• Cavernous aneurysms
• Thrombosed aneurysm
• MRI contraindications:

• Metallic implant
• Contrast allergy
• Claustrophobia
• Aspirin contraindications (or increased risk):

• Peptic ulceration
• Bleeding disorder
• Haemophilia
• Previous peptic ulceration
• Severe cardiac failure
• Severe hepatic dysfunction
• Severe renal failure
• Allergy to aspirin or NSAIDs
• Pregnancy
• Breastfeeding
• Alcoholism
• Steroid usage
• Severe asthma
• Gout
• Current warfarin or other anticoagulant use
• Current aspirin or clopidogrel use
• Current NSAID use more than once a month
• Planned treatment of the aneurysm within 3 months

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital Southampton NHS Foundation Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Diederik Bulters, FRCS (SN)

Role: PRINCIPAL_INVESTIGATOR

Wessex Neurological Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust

Locations

University Hospital Southampto NHS Foundation Trust

Southampton, Hampshire, United Kingdom

Site Status: RECRUITING

Countries

United Kingdom

Central Contacts

Sharon Davies-Dear

Role: CONTACT

sharon.davies-dear@uhs.nhs.uk

+44-(0)23-8120 5664

Emily Watkins

Role: CONTACT

emily.watkins@uhs.nhs.uk

+44-(0)23-8120 4862

Facility Contacts

Rossana Dr Romani

Role: primary

rossana.romani@uhs.nhs.uk

Other Identifiers

RHM NEU 0341

Identifier Type: -

Identifier Source: org_study_id