Risk of Uncomplicated Peptic Ulcer in the General Population
NCT ID: NCT01888588
Last Updated: 2014-07-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
4000 participants
OBSERVATIONAL
2012-09-30
2013-05-31
Brief Summary
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To estimate the relative risk of uncomplicated symptomatic peptic ulcer (UPU) associated with use of low dose aspirin (ASA) and other anti-inflammatory drugs (NSAIDs, steroids) in the general population To estimate the dose-response and duration-response associated with use of these drugs To estimate the relative risk of UPU associated with naive/non-naive use of low dose ASA in the general population To evaluate the effect of proton pump inhibitors (PPI) (alone or in combination with anti-inflammatory drugs) on the occurrence of UPU in the general population To investigate the management of low dose ASA/oral antiplatelets after UPU
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Cases
Patients with symptomatic peptic ulcer (UPU)
Risk of symptomatic peptic ulcer
Current use of drugs (ASA; NSAIDs, SSRI,PPI, H2RA) versus non-use
Control group
Control group without symptomatic peptic ulcer (UPU).
Risk of symptomatic peptic ulcer
Current use of drugs (ASA; NSAIDs, SSRI,PPI, H2RA) versus non-use
Interventions
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Risk of symptomatic peptic ulcer
Current use of drugs (ASA; NSAIDs, SSRI,PPI, H2RA) versus non-use
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
40 Years
84 Years
ALL
No
Sponsors
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AstraZeneca
INDUSTRY
Responsible Party
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Principal Investigators
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Luis A Garcia Rodriguez, MD
Role: PRINCIPAL_INVESTIGATOR
CEIFE (Centro Espanol de Investigacion Farmacoepidemiologica - Spanish Centre for Pharmacoepidemiologic Research )
Locations
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Research Site
Madrid, , Spain
Countries
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References
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Gonzalez-Perez A, Saez ME, Johansson S, Nagy P, Garcia Rodriguez LA. Risk factors associated with uncomplicated peptic ulcer and changes in medication use after diagnosis. PLoS One. 2014 Jul 8;9(7):e101768. doi: 10.1371/journal.pone.0101768. eCollection 2014.
Related Links
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Other Identifiers
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D5040N00006
Identifier Type: -
Identifier Source: org_study_id
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