Lidocaine as an Adjuvant for Ketamine in Induction of Anesthesia in Septic Shock Patients
NCT ID: NCT03640468
Last Updated: 2018-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
PHASE3
36 participants
INTERVENTIONAL
2018-12-20
2019-07-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
NCT06284473
Effect of Buffered Lidocaine With Epinephrine in Local Anesthesia
NCT03628430
Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions
NCT05906121
Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain
NCT07250867
Effect of Different Concentrations of Lidocaine in Relieving Pain in Wide Awake Hand Surgery Using Tumescence
NCT04692896
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Ketamine is an agent used for induction of anesthesia with known positive cardiovascular effects. However, these positive effects were reported in individuals with intact sympathetic nervous system. Invitro studies showed that ketamine direct action on the cardiac muscles is negative. Thus, it had been recommended that ketamine should be used with caution in hemodynamically vulnerable patients till further randomized controlled trials are present.
Lidocaine is a drug with multiple local and systemic uses. Having local anesthetic properties, lidocaine was proposed to have an anesthetic sparing effect. Lidocaine was previously reported to enhance the hypnotic effect of thiopentone, propofol, and midazolam during induction of anesthesia. Lidocaine showed a sparing effect for volatile as well as intravenous requirements for maintenance of anesthesia; thus, we hypothesize that its use as an adjuvant during induction of anesthesia in septic shock patient could provide a sparing effect for ketamine and minimize its negative circulatory sequelae.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Ketamine group
This group will receive induction of anesthesia using ketamie full dose 1 mg/kg, midazolam 0.05 mg/Kg, and normal saline 10 mL.
Ketamine full dose
This group will receive induction of anesthesia using Ketamine 1 mg/Kg
Midazolam
This group will receive midazolam 0.05 mg/Kg
Normal saline
This group will receive normal saline 10 mL
Lidocaine-ketamine group
This group will receive induction of anesthesia using Ketamie half dose 0.5 mg/kg, midazolam 0.05 mg/Kg, and lidocaine 1 mg/Kg.
Ketamine half dose
This group will receive induction of anesthesia using Ketamine 0.5 mg/Kg
Lidocaine
This group will receive lidocaince 1 mg/Kg
Midazolam
This group will receive midazolam 0.05 mg/Kg
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Ketamine full dose
This group will receive induction of anesthesia using Ketamine 1 mg/Kg
Ketamine half dose
This group will receive induction of anesthesia using Ketamine 0.5 mg/Kg
Lidocaine
This group will receive lidocaince 1 mg/Kg
Midazolam
This group will receive midazolam 0.05 mg/Kg
Normal saline
This group will receive normal saline 10 mL
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* With septic shock
* Scheduled for general anesthesia
Exclusion Criteria
* Burn patients
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Cairo University
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Ahmed Hasanin
Assistant professor of anesthesia and critical care
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Ahmed Hasanin, Professor
Role: PRINCIPAL_INVESTIGATOR
Assistant professor of anesthesia
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Cairo University
Cairo, , Egypt
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
N-128-2018
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.