Passive Smoking and LL-37 in Children

NCT ID: NCT03639376

Last Updated: 2018-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

180 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-30

Study Completion Date

2018-06-30

Brief Summary

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This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Detailed Description

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Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Conditions

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Innate Immunity Periodontal Health

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Passive smoking-exposed children

This group consists of children whose family members have smoked at home since the birth of the child.

No interventions assigned to this group

Passive smoking-unexposed children

This group consists of children whose family members have not smoked at home since the birth of the child.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Systemically healthy children

Exclusion Criteria

* Any medications known to affect defense system and periodontium
* The presence of orthodontic / intraoral appliance
Minimum Eligible Age

6 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kırıkkale University

OTHER

Sponsor Role lead

Responsible Party

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Meltem Karsiyaka Hendek

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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2016/140

Identifier Type: -

Identifier Source: org_study_id

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