Detecting Dementia in the Retina Using Optical Coherence Tomography
NCT ID: NCT03631069
Last Updated: 2021-09-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
280000 participants
OBSERVATIONAL
2019-09-01
2022-08-01
Brief Summary
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Detailed Description
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The focus of this project is to identify changes in retinal structure associated with dementia. In collaboration with bioinformatics experts at University College London (UCL), the investigators propose to analyse our repository of \>1 million retinal scans, termed optical coherence tomography (OCT), performed regularly on patients since 2008. OCT scans will be linked at a patient level to data from the Hospital Episode Statistics (HES) database to identify those who have been diagnosed with dementia or went on the develop dementia. Thus, a pseudonymised classified dataset of retinal scans will be generated for qualitative and quantitative analysis. The primary objective is to characterise changes in the layers of the retina associated with dementia. Machine learning techniques may also be employed to identify novel patterns of retinal change associated with dementia.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Dementia
People with hospital episode statistics labels of dementia
No interventions assigned to this group
Normal
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
40 Years
ALL
Yes
Sponsors
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Moorfields Eye Hospital NHS Foundation Trust
OTHER
Responsible Party
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Principal Investigators
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Pearse Keane, MD FRCOphth
Role: PRINCIPAL_INVESTIGATOR
University College, London
Locations
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Moorfields Eye Hospital NHS Foundation Trust
London, , United Kingdom
Countries
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Other Identifiers
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KEAP1004
Identifier Type: -
Identifier Source: org_study_id
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