Impact of Life Events and Psychological Stress in Rheumatoid Arthritis Set-up : Case-control Study Within a Multifactorial and Integrative Psychological Model

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

152 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-13

Study Completion Date

2019-07-04

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Rheumatoid Arthritis (RA) is an inflammatory rheumatic disease that can lead to structural damage and handicap. The RA physiopathology is multifactorial, including genetic and environmental risk factors. The identification of environmental factors implication is crucial to understand the RA mechanism, and improves the diagnosis and the treatment of the disease.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Controlling Environmental Risk Factors in Established RA

NCT05198271

Rheumatoid Arthritis

UNKNOWN NA

Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients

NCT04798053

Covid19 Rheumatic Fever Mental Disorder

COMPLETED NA

Impact of Behavioral Factors on Treatment Adherence in a Sample of Rheumatoid Arthritis Patients

NCT03754855

Arthritis, Rheumatoid

COMPLETED

Assessment of the Psychological Impact of the COVID19 (SARS-CoV-2) Pandemic on Patients With Chronic Inflammatory Rheumatism

NCT04723407

Rheumatism

UNKNOWN

Pain Evaluation in Rheumatoid Arthritis

NCT01706029

Rheumatoid Arthritis

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The physiopathology of RA is multifactorial, implicating genetic and environmental factors. Within the environmental factors, the exact role of psychological stress and life events on the onset of the disease is still under question. In clinical practice, patients usually report the occurrence of a stressing life event before the diagnosis of the disease (mourning, dismissal, divorce…). Nevertheless, literature reviews present some discrepancies and did not lead to a clear identification of the role of psychological stress in RA onset. This is mainly due to the evaluation methods of stress within those previous studies, considering stress as a unique response of the organism without taking into account personal, sociological, biological or environmental history. The aim of the study is to analyze the impact of stress on the RA onset within an integrative model, to evaluate patient assessment of the stress, and to present strategies to fix it.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Arthritis, Rheumatoid Stress Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Rheumatoid Arthritis patients

patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years

Questionnaire

Intervention Type BEHAVIORAL

Questionnaire

blood sample

Intervention Type BIOLOGICAL

7 ml whole blood for Peripheral blood

control patients

patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration…)

Questionnaire

Intervention Type BEHAVIORAL

Questionnaire

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Questionnaire

Intervention Type BEHAVIORAL

blood sample

7 ml whole blood for Peripheral blood

Intervention Type BIOLOGICAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients aged over 18 years old
* patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years.
* Speaking and understanding French language
* Being informed about the study and having given his oral consent

* patients aged over 18 years old
* patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration…)
* Speaking and understanding French language
* Being informed about the study and having given his oral consent

Exclusion Criteria

* Pregnant or breastfeeding women
* Patient who refuse to participate.

Control :

* Pregnant or breastfeeding women
* Patient who refuse to participate

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No