PEEP During Induction of Anesthesia in Small Children

NCT ID: NCT03540940

Last Updated: 2019-08-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-21

Study Completion Date

2019-08-14

Brief Summary

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Positive end-expiratory pressure (PEEP) applied during induction of anesthesia prevents atelectasis formation and increases the duration of nonhypoxic apnea in obese and nonobese patients. PEEP also prevents atelectasis formation in pediatric patients. Because pediatric patients arterial desaturation during induction of anesthesia develops rapidly, we studied the clinical benefit of PEEP applied during anesthesia induction.

Detailed Description

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Conditions

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Pediatric Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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zero positive end expiratory pressure

Group Type EXPERIMENTAL

ZEEP

Intervention Type OTHER

0 cmH2O positive end expiratory pressure

Positive end expiratory pressure

Group Type EXPERIMENTAL

PEEP

Intervention Type OTHER

7cmH2O positive end expiratory pressure

Interventions

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PEEP

7cmH2O positive end expiratory pressure

Intervention Type OTHER

ZEEP

0 cmH2O positive end expiratory pressure

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* pediatric patients undergoing general anesthesia using endotracheal intubation

Exclusion Criteria

* previous history of lung disease
* anticipated difficulty in airway management
Minimum Eligible Age

1 Month

Maximum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hee-Soo Kim

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Hee-Soo Kim, Professor

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Hee-Soo Kim

Seoul, Soul-t'ukpyolsi, South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kim EH, Lee JH, Jang YE, Ji SH, Cho SA, Kim JT, Kim HS. Effect of positive end-expiratory pressure during anaesthesia induction on non-hypoxic apnoea time in infants: A randomised controlled trial. Eur J Anaesthesiol. 2021 Oct 1;38(10):1012-1018. doi: 10.1097/EJA.0000000000001400.

Reference Type DERIVED
PMID: 33259454 (View on PubMed)

Other Identifiers

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H 1804-100-938

Identifier Type: -

Identifier Source: org_study_id

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