Individualized Positive End-expiratory Pressure Evaluation Using the Intratidal Compliance-volume Profile in Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-13

Study Completion Date

2019-12-20

Brief Summary

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The investigators assess the changes in respiratory compliance according to different levels of positive end expiratory pressure (PEEP) in children under general anesthesia. In addition, the investigators evaluate the intratidal compliance-volume profile at each PEEP level and determine the optimal PEEP level during anesthesia.

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Detailed Description

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Conditions

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Lung Compliance

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Children

Children who receive elective surgery under general anesthesia and are supported by mechanical ventilation

Group Type EXPERIMENTAL

Positive end expiratory pressure (PEEP)

Intervention Type PROCEDURE

The different levels of PEEP, 5 cmH2O, 8 cmH2O and 12 cmH2O, are applied serially. Mean respiratory compliance and intratidal compliance-volume profile are evaluated.

Interventions

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Positive end expiratory pressure (PEEP)

The different levels of PEEP, 5 cmH2O, 8 cmH2O and 12 cmH2O, are applied serially. Mean respiratory compliance and intratidal compliance-volume profile are evaluated.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Children undergoing surgery more than 1 hour under general anesthesia
* American Society Anesthesiologist physical status I, II

Exclusion Criteria

* History of lung resection
* History of bronchopulmonary dysplasia or respiratory distress syndrome
* Abnormalities in chest radiography
* Laparoscopic surgery
* Abdominal surgery

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No