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Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

NCT ID: NCT03431064

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-21

Study Completion Date

2027-12-31

Brief Summary

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In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.

It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Detailed Description

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In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.

It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Conditions

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Anesthesia Intravenous Fluid Blood Pressure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Surgical patients less than 18 years old

Patients less than 18 years old having surgery with general anesthesia at Boston Children's Hospital

Lung Recruitment Maneuver

Intervention Type OTHER

Lung Recruitment Maneuver by Anesthesiologist

Fluid Administration

Intervention Type OTHER

Administration of IV Fluid by Anesthesiologist

Interventions

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Lung Recruitment Maneuver

Lung Recruitment Maneuver by Anesthesiologist

Intervention Type OTHER

Fluid Administration

Administration of IV Fluid by Anesthesiologist

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 0 to \< 18 years old
* Undergoing surgery at Boston Children's Hospital under general anesthesia
* mechanically ventilated with an endotracheal tube
* Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure

Exclusion Criteria

* Prematurity
* Low birth weight
* Congenital heart disease
* Left or right ventricular dysfunction
* Cardiac arrhythmia
* Pulmonary hypertension
* Preoperative parenchymal or interstitial lung disease
* Intracranial hypertension
* Poor transthoracic acoustic window
* Obesity
* Allergy to ultrasound transmission gel
* Need for single lung ventilation
* Systemic hypertension on antihypertensive medications
Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Masimo Corporation

INDUSTRY

Sponsor Role collaborator

Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Viviane Nasr

Cardiac Anesthesiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Viviane Nasr, MD

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

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Boston Children's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Viviane Nasr, MD

Role: CONTACT

Phone: 617-355-6225

Email: [email protected]

Facility Contacts

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Viviane Nasr, MD

Role: primary

Other Identifiers

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IRB-P00025702

Identifier Type: -

Identifier Source: org_study_id