Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
15 participants
OBSERVATIONAL
2018-04-30
2019-08-01
Brief Summary
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Detailed Description
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In a previous study, the investigators showed that the function of the right side of the heart (the right heart) is decreased following lung resection. The decrease in right heart (the part that supplies blood to the lungs) function was associated with a prolonged stay in the high dependency unit and blood markers indicating damage to the heart. The process by which the damage occurs is poorly understood, but it is thought that an increase in the forces preventing the right heart pumping blood (resistance) is to blame. The decrease in function in the right heart may be triggered during surgery by the diminished blood supply to the cancerous lung and, and maintained post operatively, as lung resection can cause a long-term increase in resistance.
Diseases that cause an increase in resistance to the right heart have been shown to cause damage to different parts of the right heart. An acute sudden increase in resistance can cause inflammation, thinning and scarring whilst a long-term increase in resistance causes the right heart to thicken. The investigators believe that the potential damage during the operation could cause permanent damage to the right heart and contribute to shortness of breath and functional limitation.
To investigate the potential inflammation/scarring and the function of the heart the investigators will image the heart with specialised Magnetic Resonance Imaging (MRI) scans.
The aim of the research is to determine whether inflammation occurs in the right heart during and following lung resection and, if so, does it result in scarring?. The investigators will compare the function of the right heart before, during and after surgery to determine if inflammation contributes to the decrease in right heart function following lung resection seen in our previous study. The investigators anticipate that the study will increase understanding of how the right heart may be damaged by lung resection. The investigators believe this will guide further studies aiming to prevent such damage, ultimately limiting the disabling breathlessness and decrease in heart function that so greatly affects patients' lives.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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lung resection
Patients with suspected lung cancer undergoing lung resection by anatomic lobectomy
Lung Resection
Lung resection surgery
Interventions
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Lung Resection
Lung resection surgery
Eligibility Criteria
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Inclusion Criteria
2. Age \>16 years
3. Planned elective lung resection by VATS or open lobectomy
Exclusion Criteria
2. On-going participation in any investigational research which could undermine the scientific basis of the study
3. Wedge, segmental or sub-lobar lung resection
4. Pneumonectomy
5. Isolated right middle lobectomy
6. Atrial fibrillation at baseline
7. Contraindication to cardiac magnetic resonance imaging
1. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant
2. Aneurysm clips
3. Metal injuries to the eye
4. Loose metal in a part of the body
8. Contraindication to IV Gadolinium (contrast) administration:
1. Acute or chronic renal failure
2. Allergy to contrast
16 Years
ALL
No
Sponsors
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University of Glasgow
OTHER
Responsible Party
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Dr Ben Shelley
Consultant Cardio-thoracic Anaesthesia and Critical Care
Locations
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Golden Jubilee National Hospital
Glasgow, Strathclyde, United Kingdom
Countries
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Facility Contacts
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Other Identifiers
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17/ANAES/06
Identifier Type: -
Identifier Source: org_study_id
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