Right Side of Heart Function After Lung Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

25 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-08-31

Study Completion Date

2016-08-31

Brief Summary

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The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.

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Detailed Description

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Lung cancer is the second most common cancer in the UK. In suitable cases the best chance of cure is surgical resection. Studies suggest that lung resection is associated with right ventricular (RV) dysfunction, predisposing to complications and post-operative dyspnoea. Studies of RV function following lung resection have been hampered by the limitations of the techniques used. In addition the mechanism of RV dysfunction has remained elusive.

In this prospective observational study the RV response to lung resection will be characterised by sequential assessment of right ventricular ejection fraction (RVEF) measured using cardiovascular magnetic resonance (CMR). CMR is non-invasive, involves no ionising radiation and due to its high spatial resolution is the gold standard for assessing RV volumes. Comprehensive CMR and echocardiographic assessment of the pulmonary vascular - RV axis will allow us to interpret peri-operative changes in RVEF in the context of RV contractility and loading indices. In addition, contemporaneous blood samples will be taken for measurement of biomarkers of myocardial and endothelial dysfunction and systemic inflammation.

With increased understanding of the mechanisms involved, it may be possible to prevent RV dysfunction; reducing complication rates, hospital stay and costs and ameliorating long term dyspnoea.

Conditions

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Lung Cancer Ventricular Failure, Right

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Study population - lung resection

Patients with suspected lung cancer undergoing lung resection by anatomic lobectomy

Lung resection

Intervention Type PROCEDURE

Interventions

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Lung resection

Intervention Type PROCEDURE

Other Intervention Names

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Pulmonary lobectomy

Eligibility Criteria

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Inclusion Criteria

1. Provision of informed consent
2. Age \>16 years
3. Planned elective lung resection by lobectomy

Exclusion Criteria

1. Pregnancy
2. On-going participation in any investigational research which could undermine the scientific basis of the study
3. Contraindications to magnetic resonance imaging:

i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in an part of the body
4. Wedge / segmental / sub-lobar lung resection
5. Pneumonectomy
6. Isolated right middle lobectomy

Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No