Behavioral Economic Analysis of Demand for Marijuana

NCT ID: NCT03518567

Last Updated: 2024-02-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 133 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-10-15
• Study Completion Date: 2021-05-24

Brief Summary

This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.

Detailed Description

This laboratory study will employ a multi-session experimental design to examine craving for marijuana, the effect of marijuana administration (High THC) on behavioral economic demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly. The relationship between hypothetical and actual demand for marijuana will be examined. We will also investigate relationship between demand for marijuana and indices of marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly to obtain a final sample of 85 with complete data (15% of attrition). Participants will be tested at a baseline session and during two experimental sessions (an ad libitum marijuana smoking session and a marijuana smoking topography session). This study will confirm the utility of the hypothetical marijuana purchase task as a reliable and valid tool for assessing behavioral economic marijuana demand.

Conditions

Marijuana Smoking

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

High THC dose (6% THC)

Smoked marijuana cigarettes (High THC dose \[6% THC\])

Group Type: EXPERIMENTAL

Smoked marijuana cigarettes: High THC dose (6% THC)

Intervention Type: DRUG

Smoked marijuana cigarettes (High THC dose \[6% THC\])

Interventions

Smoked marijuana cigarettes: High THC dose (6% THC)

Smoked marijuana cigarettes (High THC dose \[6% THC\])

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months
• English-speaking
• negative urine toxicology screen for drugs other than marijuana
• non-treatment seeking
• purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured

Exclusion Criteria

• positive pregnancy test
• nursing
• inability to use contraception during the study
• poor physical health
• positive breath alcohol concentration
• diagnosis of a current affective disorder, psychosis, and panic disorder
• self-report of past serious adverse reaction to marijuana
• current psychotropic drug use
• smoking more than 20 tobacco cigarettes per day
• inability to abstain from marijuana for 15 hours
• body mass index outside 18.5-30 kg/m2 range

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Brown University

OTHER

Sponsor Role: lead

Responsible Party

Elizabeth Aston

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Elizabeth Aston, PhD

Role: PRINCIPAL_INVESTIGATOR

Brown University

Locations

Brown University

Providence, Rhode Island, United States

Countries

United States

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

#1502001185

Identifier Type: -

Identifier Source: org_study_id