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Stress and Marijuana Cue-elicited Craving and Reactivity

NCT ID: NCT00613405

Last Updated: 2013-04-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

87 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.

Detailed Description

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Although use of marijuana is widespread, little research has focused on the treatment of marijuana use disorders or on predictors of relapse. Although several factors contributing to relapse have been explored in other dependencies (i.e., alcohol, cocaine), little research has focused on drug cue-related or stress-induced relapse in marijuana-dependent individuals. Cue reactivity is a construct measured in a laboratory procedure where an individual's subjective, behavioral, and physiological responses are assessed following exposure to drug-related environmental cues or stressors. Investigating the effects of drug-related environmental cues and stress in marijuana-dependent individuals will be useful in guiding treatment development.

Conditions

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Cannabis Use Disorders

Keywords

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substance-related disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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Stress + cue exposure

Individuals were exposed to the Trier Social Stress Test (TSST) as well as neutral cues and marijana cues.

Group Type EXPERIMENTAL

Stress + cue exposure

Intervention Type OTHER

Trier Social Stress Task(TSST): subject is asked to give a talk and perform a math task in front of an audience, follwed by neutral and marijuana cue exposure.

No stress + cue exposure

Individuals were not exposed to a stress test, but were exposed to neutral cues and marijuana cues.

Group Type EXPERIMENTAL

No stress + cue exposure

Intervention Type OTHER

Neutral and marijuana-associated cue exposure (scripted imagery, in vivo cues).

Interventions

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Stress + cue exposure

Trier Social Stress Task(TSST): subject is asked to give a talk and perform a math task in front of an audience, follwed by neutral and marijuana cue exposure.

Intervention Type OTHER

No stress + cue exposure

Neutral and marijuana-associated cue exposure (scripted imagery, in vivo cues).

Intervention Type OTHER

Other Intervention Names

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Stress stask, TSST marijuana cue exposure, neutral cue exposure

Eligibility Criteria

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Inclusion Criteria

* Meets Diagnostic and Statistical Methods (DSM)-IV Criteria for Marijuana Dependence
* Between the ages of 18 and 65
* Must abstain from marijuana use the day of testing and other drug use three days prior to testing

Exclusion Criteria

* Must not be taking any psychoactive medication, or medication that alters the hypothalamic pituitary adrenal (HPA) Axis functioning
* Must not be taking any medications that alter heart rate or skin conductance monitoring
* Cannot meet criteria for current major Axis I disorder (may alter response to stress)
* Cannot be morbidly obese (Body Mass Index \>39)
* Cannot meet current abuse or dependence criteria of other substances in past 90 days
* Must not have a medical condition that impacts HPA functioning (Hypertension, chronic pain, Addison's disease)
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

Medical University of South Carolina

OTHER

Sponsor Role lead

Responsible Party

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Aimee McRae-Clark

Associate Professor of Psychiatry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aimee L McRae, PharmD, BCPP

Role: PRINCIPAL_INVESTIGATOR

Medical University of South Carolina

Locations

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Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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R21DA022424

Identifier Type: NIH

Identifier Source: secondary_id

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R21DA022424-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

HR#17195

Identifier Type: -

Identifier Source: org_study_id