Multiple Myeloma (MM) Profile in Brazil: A Retrospective Observational Analysis

NCT ID: NCT03506386

Last Updated: 2021-02-08

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

943 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-08-09

Study Completion Date

2020-01-27

Brief Summary

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The purpose of this study is to present a descriptive analysis of demographic and clinical characteristics of the participants, as well as of the treatment patterns for multiple myeloma (MM) in Brazil.

Detailed Description

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Participants with a diagnosis of MM will be observed in this retrospective study. Data collected for the study will include identification, demographic, baseline data on MM, additional baseline laboratory, initial treatment for MM, subsequent treatment for MM, and outcome.

The study will enroll approximately 1000 participants.

This multi-center trial will be conducted in five geographic regions of Brazil. For each participant, data collection will comprise the longest possible period of time since the diagnosis of MM (within the eligibility window of time, between January 1, 2008 and December 31, 2016) and the cut-off date for data collection (December 31, 2016), unless a participant has died or been lost to follow-up before that. The study is planned to last for approximately 24 months since its initiation (initiation defined as the initiation visit for the first site).

Conditions

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Multiple Myeloma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Multiple Myeloma Participants

Participants with multiple myeloma (MM) were observed retrospectively since the diagnosis up to death or lost to follow-up within the eligibility window of time (between January 1, 2008 and December 31, 2016), in this study.

No Intervention

Intervention Type OTHER

As it was an observational study, no intervention was administered.

Interventions

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No Intervention

As it was an observational study, no intervention was administered.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Provision of written informed consent, for participants who are alive and not lost to follow-up (for participants already deceased or lost follow up, informed consent should have been waived by the corresponding ethics review board \[ERB\]).
2. Documented diagnosis of MM by the responsible physician between January 1, 2008, and December 31, 2016.
3. Absence of any plasma-cell disorder other than MM.
4. Absence of any immunoglobulin-related disorder other than MM.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Takeda

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor Clinical Science

Role: STUDY_DIRECTOR

Takeda

Locations

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Centro de Hematologia e Oncologia (CEHON)

Salvador, Estado de Bahia, Brazil

Site Status

Hospital Sao Rafael

Salvador, Estado de Bahia, Brazil

Site Status

Hospital das Clinicas da UFG

Goiânia, Goiás, Brazil

Site Status

Hospital das Clinicas da UFMG

Belo Horizonte, Minas Gerais, Brazil

Site Status

Fundacao IMEPEN

Juiz de Fora, Minas Gerais, Brazil

Site Status

Clinica de Tratamento e Pesquisa em Hematologia LTDA.

Cuiabá, Mount, Brazil

Site Status

Hospital das Clinicas da UFPR

Curitiba, Paraná, Brazil

Site Status

CIONC - Centro Integrado de Oncologia de Curitiba

Curitiba, Paraná, Brazil

Site Status

Universidade Federal do Rio de Janeiro

Rio de Janeiro, Rio de Janeiro, Brazil

Site Status

Hospital Sao Vicente de Paulo

Passo Fundo, Rio Grande do Sul, Brazil

Site Status

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Centro de Pesquisas Oncologicas (CEPON)

Florianópolis, Santa Catarina, Brazil

Site Status

Hospital Amaral Carvalho

Jaú, São Paulo, Brazil

Site Status

Hospital do Servidor Publico de SP

São Paulo, São Paulo, Brazil

Site Status

Clinica Sao Germano

São Paulo, São Paulo, Brazil

Site Status

Hospital das Clinicas da FMUSP

São Paulo, São Paulo, Brazil

Site Status

Casa de Saude Santa Marcelina

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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NDMM-5004

Identifier Type: -

Identifier Source: org_study_id

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