Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

NCT ID: NCT03503084

Last Updated: 2018-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-01

Study Completion Date

2009-12-31

Brief Summary

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The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Detailed Description

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Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

Conditions

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Physiological Effect of TCC on Glucose Metabolism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.
Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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TCC group

Classical Yang's TCC exercise

Group Type EXPERIMENTAL

Classical Yang's TCC exercise

Intervention Type BEHAVIORAL

Interventions

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Classical Yang's TCC exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* TCC practitioners in a TCC training center in Taiwan over 50 years of age
* Healthy subjects without TCC experience over 50 years of age

Exclusion Criteria

* Subjects who had major cardiopulmonary disease
* Subjects who have diabetes mellitus, renal or liver disease
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role collaborator

Changhua Christian Hospital

OTHER

Sponsor Role lead

Responsible Party

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Cheng-Deng Kuo

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Cheng-Deng Kuo, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Changhua Christian Hospital

Locations

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Wan-An Lu

Yilan, , Taiwan

Site Status

Countries

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Taiwan

References

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Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9. doi: 10.1007/BF00280883.

Reference Type RESULT
PMID: 3899825 (View on PubMed)

Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15-26. doi: 10.1152/ajpendo.00645.2007. Epub 2007 Oct 23.

Reference Type RESULT
PMID: 17957034 (View on PubMed)

Couillard C, Despres JP, Lamarche B, Bergeron J, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study. Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1226-32. doi: 10.1161/hq0701.092137.

Reference Type RESULT
PMID: 11451756 (View on PubMed)

Lu WA, Kuo CD. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc. 2003 Dec;35(12):1972-6. doi: 10.1249/01.MSS.0000099242.10669.F7.

Reference Type RESULT
PMID: 14652490 (View on PubMed)

Lu WA, Kuo CD. Three months of Tai Chi Chuan exercise can reduce serum triglyceride and endothelin-1 in the elderly. Complement Ther Clin Pract. 2013 Nov;19(4):204-8. doi: 10.1016/j.ctcp.2013.06.007. Epub 2013 Jul 27.

Reference Type RESULT
PMID: 24199974 (View on PubMed)

Salgado AL, Carvalho Ld, Oliveira AC, Santos VN, Vieira JG, Parise ER. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. Arq Gastroenterol. 2010 Apr-Jun;47(2):165-9. doi: 10.1590/s0004-28032010000200009.

Reference Type RESULT
PMID: 20721461 (View on PubMed)

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10. doi: 10.1210/jcem.85.7.6661.

Reference Type RESULT
PMID: 10902785 (View on PubMed)

Other Identifiers

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V98E2-014

Identifier Type: -

Identifier Source: org_study_id

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