Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery
NCT ID: NCT03498235
Last Updated: 2020-06-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
110 participants
INTERVENTIONAL
2018-03-01
2020-06-30
Brief Summary
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Detailed Description
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Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration \>1.1 minimum alveolar concentration（MAC),ICP increases because of cerebral vasodilatation；on the other hand ,propofol constricts the blood vessels and ICP decreases.
ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum .
Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
DOUBLE
Study Groups
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Team Sevoflurane
Sevoflurane
In Team Sevoflurane,patients undergo sevoflurane.
Team Propofol
Propofol
In Team Propofol ,anesthesia is maintained with propofol
Interventions
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Sevoflurane
In Team Sevoflurane,patients undergo sevoflurane.
Propofol
In Team Propofol ,anesthesia is maintained with propofol
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
60 Years
FEMALE
No
Sponsors
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Obstetrics & Gynecology Hospital of Fudan University
OTHER
Responsible Party
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Weilian Geng
Director,Clinical Research
Locations
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Obstetrics & Gynecology Hospital of Fudan University
Shanghai, Shanghai Municipality, China
Countries
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References
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Geng W, Chen C, Sun X, Huang S. Effects of sevoflurane and propofol on the optic nerve sheath diameter in patients undergoing laparoscopic gynecological surgery: a randomized controlled clinical studies. BMC Anesthesiol. 2021 Jan 27;21(1):30. doi: 10.1186/s12871-021-01243-7.
Other Identifiers
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V2018-2
Identifier Type: -
Identifier Source: org_study_id
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