Effects of OCTA-guided PDT in Acute CSC

NCT ID: NCT03497000

Last Updated: 2018-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-01

Study Completion Date

2018-03-27

Brief Summary

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OCTA-guided PDT is as safe and effective as ICGA-guided PDT in the treatment of acute central serous chorioretinopathy. Or OCTA-guided PDT is more effective than ICGA-guided PDT in the treatment of acute central serous chorioretinopathy, safe as well.

Detailed Description

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Conditions

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Central Serous Chorioretinopathy Tomography, Optical Coherence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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OCTA group

Patients in this group underwent OCTA-guided half-dose photodynamic therapy.

Group Type EXPERIMENTAL

OCTA-guided Photodynamic therapy

Intervention Type PROCEDURE

Half-dose photodynamic therapy using verteporfin under the guidance of OCTA

ICGA group

Patients in this group underwent normal ICGA-guided half dose photodynamic therapy.

Group Type ACTIVE_COMPARATOR

ICGA-guided Photodynamic therapy

Intervention Type PROCEDURE

Half-dose photodynamic therapy using verteporfin under the guidance of ICGA

Interventions

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OCTA-guided Photodynamic therapy

Half-dose photodynamic therapy using verteporfin under the guidance of OCTA

Intervention Type PROCEDURE

ICGA-guided Photodynamic therapy

Half-dose photodynamic therapy using verteporfin under the guidance of ICGA

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA
* Presence of SRF and/or serous pigment epithelial detachment on OCT
* Presence of abnormal dilated choroidal vasculature in ICGA

Exclusion Criteria

* Patients with other ocular conditions commonly associated with SRF, such as choroidal neovascularization, polypoidal choroidal vasculopathy (PCV), diabetic retinopathy, retinal vascular occlusion, Coat's disease
* Any disease that may affect the quality of imaging (quality of OCTA images \< 6), such as cataract, high myopia or nystagmus
* History of ocular surgeries including retinal laser
* Pregnancy
* Any uncontrolled systemic disease
* Any condition rendering patients intolerable to image acquisition
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Natural Science Foundation of China

OTHER_GOV

Sponsor Role collaborator

Peking University People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Mingwei Zhao

Head of Ophthalmology, Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mingwei Zhao, M.D

Role: STUDY_DIRECTOR

Peking University People's Hospital

Locations

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People's Hospital of Peking University

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Hu J, Qu J, Li M, Sun G, Piao Z, Liang Z, Yao Y, Sadda S, Zhao M. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY-GUIDED PHOTODYNAMIC THERAPY FOR ACUTE CENTRAL SEROUS CHORIORETINOPATHY. Retina. 2021 Jan 1;41(1):189-198. doi: 10.1097/IAE.0000000000002795.

Reference Type DERIVED
PMID: 32343102 (View on PubMed)

Other Identifiers

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Peking UPH

Identifier Type: -

Identifier Source: org_study_id

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