The Role of Music Stimulation in Disorders of Consciousness State: an fMRI Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

11 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-12-31

Study Completion Date

2018-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia

NCT04464265

Healthy

COMPLETED PHASE4

Clinical Evaluation of Chronic Consciousness Disorders Using Resting-state EEG and ERP

NCT05949528

Disorders of Consciousness

UNKNOWN

Real-time fMRI Neurofeedback Training on the Anterior Insula Based on Interoceptive Processing

NCT05260749

Healthy

COMPLETED NA

Effects of Emotional Stimuli in Patients With Disorders of Consciousness

NCT03502837

Disorder of Consciousness

COMPLETED

The Usage of High-resolution Magnetic Resonance Imaging in Patients With Disorders of Consciousness for Early Diagnosis

NCT03475511

High-resolution Magnetic Resonance Imaging; Disorders of Consciousness

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Background: Sensory stimulations were used widely to evaluate the preserved cerebral functions for these patients with disorders of consciousness. Among these, the most alerting or common stimuli are probably familiar voice and music.

Objective: The aim of the present study was to evaluated the neural effect of music on the cerebral activation in unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) by using functional magnetic resonance imaging (fMRI).

Methods: Eleven severely brain-damaged patients (6 UWS and 5 MCS) were assessed by functional magnetic resonance imaging while they were exposed under the condition of their personal music. To examine the prognostic value of these patients, longitudinal behavioral assessments were repeatedly conducted by means of the CRS-R after fMRI acquisition.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Vegetative State Minimally Conscious State

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

patients with disorders of consciousness

patients with disorders of consciousness from several brain injury have been clinically classified into coma, unresponsive wakefulness syndrome and minimally conscious state. These patients were scaned by functional magnetic resonance imaging.

functional magnetic resonance imaging

Intervention Type DIAGNOSTIC_TEST

Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

functional magnetic resonance imaging

Patients with disorders of consciousness were assessed by functional magnetic resonance imaging while they were exposed under the condition of music.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Coma Recovery Scale-Revised

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age ≥ 18 years old;
* no administration of neuromuscular blockers or sedation within the 24 hours of enrolment;
* brain damage with eye opening (indicating wakefulness and rest cycles)