Research for Associated Genes for Gastric Cancer in Family Member With Affected First-Degree Relatives
NCT ID: NCT03486574
Last Updated: 2023-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
105 participants
OBSERVATIONAL
2016-12-07
2022-12-31
Brief Summary
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Because Germline mutation is believed to be a key aspect of cancer predisposition, we plan to recruit persons with 2 or more affected family members in three-generation pedigree. The investigators will perform a whole-exome sequencing using DNA from blood samples of families including gastric cancer patients and non-gastric cancer patients
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Detailed Description
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Enroll criteria:
1\) Gastric cancer patients and their first-degree relatives and 2) family with two or more gastric cancer patients within three-generation pedigree.
A three-generation pedigree will be used for diagnostic consideration or risk assessment of rare variation.
Personal history will be acquired by questionnaire which asks smoking, alcohol intake, dietary preference, socioeconomic information and history of previous eradication of HP. For any family member with gastric cancer, age at diagnosis, histology type, methods of treatment or pathological reports will be evaluated.
2\> Whole exome sequencing, variant annotation, filtering and prioritization After whole exome sequencing, functional annotation of genetic variants will be conducted using ANNOVAR.
3\> Linkage analyses To perform variant and gene-based linkage analysis in pedigrees, data will be analyzed using pedigree-VAAST.
4\> Validation using a genechip
Conditions
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Study Design
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FAMILY_BASED
PROSPECTIVE
Study Groups
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Gastric cancer
Pathologically proven diseases after upper gastroendoscopy and biopsy. Previous pathological reports and endoscopic image can be used.
Positive result from pathological test
Presence/absence of gastric cancer will be evaluated by upper gastroendoscopy or results of pathological test
non-gastric cnacer
Rull out gastric cancer by upper gastroendoscopy. The results 3 moths before enrollment is available.
No interventions assigned to this group
Interventions
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Positive result from pathological test
Presence/absence of gastric cancer will be evaluated by upper gastroendoscopy or results of pathological test
Eligibility Criteria
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Inclusion Criteria
* Members in family with two or more gastric cancer patients within three- generation pedigree
Exclusion Criteria
ALL
Yes
Sponsors
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Seoul National University Bundang Hospital
OTHER
Responsible Party
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Nayoung Kim
Professor
Locations
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Countries
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Other Identifiers
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B-1610/366-303
Identifier Type: -
Identifier Source: org_study_id
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