Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
18064 participants
OBSERVATIONAL
2005-03-01
2014-12-31
Brief Summary
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Detailed Description
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The Tzu Chi Health Study (TCHS) recruited 6002 participants who came to the Buddhist Tzu Chi Dalin General Hospital for health examination. All participants were interviewed on basic information, medical history, lifestyle, and diet. Biochemical and anthropometric data was collected through a health examination:
Biochemical variables: CBC, fasting glucose, lipid profile (TCH, LDL, HDL, TG), BUN, Cr, ALT, AST, and UA. In addition, homocysteine, serum vitamin B12, folate, and C-reactive protein (CRP) are available for 1500 subjects.
Blood: Extra blood samples have been obtained and stored for 3500 subjects and will be available for future investigation.
Anthropometric variables: body weight, height, waist circumference, % body fat (with BIA), blood pressure, pulse wave velocity, bone mineral density through DXA (at spine for female and hip for male), lung function test (spirometric), abdominal sonography, colonoscopy, esophageal-gastro-duodenal-scopy, chest X-ray, KUB.
Follow-up: Individual baseline data were linked to the National Health Insurance Database and the National Death Registry to ascertain disease outcomes at the Health and Welfare Data Science Center.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Tzu Chi Vegetarian Study
12062 Tzu Chi volunteers of the Buddhist Tzu Chi Foundation recruited throughout communities in Taiwan in the year 2005. All participants filled out a self-administered questionnaire on basic information, medical history, lifestyle, and diet. Diet exposure: 1/3 vegetarians, 2/3 nonvegetarians.
Diet Exposure
Vegetarian diet vs nonvegetarian diet
Tzu Chi Health Study
6002 participants who came for health examination at the Dalin Tzu Chi Hospital between the years 2007 to 2009. 77% were Tzu Chi volunteers. All participants were interviewed on a structured questionnaire including basic information, medical history, lifestyle, and diet, and received a comprehensive health examination. Diet exposure: 1/3 vegetarians, 2/3 nonvegetarians.
Diet Exposure
Vegetarian diet vs nonvegetarian diet
Interventions
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Diet Exposure
Vegetarian diet vs nonvegetarian diet
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Participants already with study outcome (disease) prior to enrollment in the study.
* Participants with missing covariates
18 Years
ALL
Yes
Sponsors
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Dalin Tzu Chi General Hospital
OTHER
Responsible Party
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Principal Investigators
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Chin-Lon Lin, MD
Role: STUDY_CHAIR
Dalin Tzu Chi General Hospital
Locations
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Dalin Tzu Chi Hospital
Chiayi City, , Taiwan
Countries
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References
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Chiu THT, Liu CH, Chang CC, Lin MN, Lin CL. Vegetarian diet and risk of gout in two separate prospective cohort studies. Clin Nutr. 2020 Mar;39(3):837-844. doi: 10.1016/j.clnu.2019.03.016. Epub 2019 Mar 27.
Chiu THT, Chang HR, Wang LY, Chang CC, Lin MN, Lin CL. Vegetarian diet and incidence of total, ischemic, and hemorrhagic stroke in 2 cohorts in Taiwan. Neurology. 2020 Mar 17;94(11):e1112-e1121. doi: 10.1212/WNL.0000000000009093. Epub 2020 Feb 26.
Chiu THT, Chang CC, Lin CL, Lin MN. A Vegetarian Diet Is Associated with a Lower Risk of Cataract, Particularly Among Individuals with Overweight: A Prospective Study. J Acad Nutr Diet. 2021 Apr;121(4):669-677.e1. doi: 10.1016/j.jand.2020.11.003. Epub 2020 Dec 11.
Chang CM, Chiu THT, Chang CC, Lin MN, Lin CL. Plant-Based Diet, Cholesterol, and Risk of Gallstone Disease: A Prospective Study. Nutrients. 2019 Feb 4;11(2):335. doi: 10.3390/nu11020335.
Lin CL, Wang JH, Chang CC, Chiu THT, Lin MN. Vegetarian Diets and Medical Expenditure in Taiwan-A Matched Cohort Study. Nutrients. 2019 Nov 6;11(11):2688. doi: 10.3390/nu11112688.
Chen YC, Chang CC, Chiu THT, Lin MN, Lin CL. The risk of urinary tract infection in vegetarians and non-vegetarians: a prospective study. Sci Rep. 2020 Jan 30;10(1):906. doi: 10.1038/s41598-020-58006-6.
Other Identifiers
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TCHS-02
Identifier Type: -
Identifier Source: org_study_id
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