Clinical Trial to Assess the Effects of Low-fat Dairy on Systolic Blood Pressure

NCT ID: NCT01463085

Last Updated: 2012-05-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2012-08-31

Brief Summary

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The purpose of this study is to determine if increased consumption of low-fat dairy can reduce blood pressure and improve endothelial function in men and women with pre or stage-1 hypertension.

Detailed Description

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Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Control foods

3 servings per day of control foods

Group Type PLACEBO_COMPARATOR

Low-fat dairy

Intervention Type OTHER

Dietary Intervention of 3 servings per day of low-fat dairy

Low-fat dairy

3 servings per day of low-fat dairy products

Group Type EXPERIMENTAL

Low-fat dairy

Intervention Type OTHER

Dietary Intervention of 3 servings per day of low-fat dairy

Interventions

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Low-fat dairy

Dietary Intervention of 3 servings per day of low-fat dairy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject is a female or male, 20-69 years of age, inclusive.
* Subject has a BMI of 18.5 to 39.9 kg/m2, inclusive.
* Subject has resting blood pressure measurements meeting the criteria for pre-hypertension (SBP = 120 to 139 mm Hg and/or DBP = 80 to 89 mm Hg) or stage 1 hypertension (SBP = 140 to 159 mm Hg or DBP = 90 to 99 mm Hg)
* Subject reports history of consuming, on average, ≤2 servings/d of dairy foods as part of their normal diet
* Subject is willing to consume ≤1 serving/d of dairy foods (other than the study products provided) during each treatment phase.
* Subject is willing to maintain a stable body weight and habitual diet and physical activity patterns throughout the trial, with the exception of specific study instructions related to study product intake, alcohol intake, and physical activity.

Exclusion Criteria

* Subject has known coronary heart disease (CHD) or a CHD risk equivalent
* Subject has a history of any major trauma or major surgical event
* Subject has digital deformities that would prevent EndoPAT measurements.
* Subject has used medications known to alter body weight
* Subject has used medications or dietary supplements that, in the opinion of the Investigator, have strong potential to influence blood pressure or endothelial function
* Subject has extreme dietary habits (e.g., Atkins diet, very high protein/low carbohydrate).
Minimum Eligible Age

20 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BioFortis

OTHER

Sponsor Role collaborator

Provident Clinical Research

OTHER

Sponsor Role collaborator

Dairy Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kevin C Maki, PhD

Role: STUDY_DIRECTOR

Biofortis - Provident Clinical Research

Locations

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Biofortis - Provident Clinical Research

Glen Ellyn, Illinois, United States

Site Status

Countries

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United States

Other Identifiers

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PRV-11022

Identifier Type: -

Identifier Source: org_study_id

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