Chinese Second Hip Fracture Evaluation

NCT ID: NCT03461237

Last Updated: 2025-08-17

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 3000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-01
• Study Completion Date: 2026-11-30

Brief Summary

1. To Compare overall rates of second hip fractures in both genders,

2. To determine the effect of hip fracture on proximal femoral volumetric bone mineral density (vBMD), bone structure and muscle by quantitative computed tomography(QCT),

3. To evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk.

4. To identify the differences between femoral neck fracture and trochanter fracture following hip fracture

Detailed Description

Osteoporotic hip fracture is a great harm among elderly people, for whom disability and death often occurs. Furthermore, sustaining an osteoporotic hip fracture increases the risk of a subsequent fracture. However, the risk factors of subsequent hip fractures are less studied and the proximal femur bone structure and muscle changes following first hip fracture are little known.

Therefore, we propose to conduct an observational and perspective study to assess the effect of hip fracture on proximal femoral bone and muscle using quantitative computed tomography (QCT), as well as to evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk. As hip fractures are divided into two major anatomic based types in clinical: femoral neck fractures (intracapsular) and trochanter fractures (extracapsular), the fundamental objective also includes identifying bone and muscle differences in a union activity between the two type fractures. Compared with duel-energy x-ray absorptiometry (DXA), QCT offers the advantage of selective measurement of the metabolically active and structurally important trabecular bone in the proximal femoral. Volumetric BMD and structure of proximal femoral and muscle around hip will be measured with QCT. The CT scanner will be the clinical CT scanner of the local participated center. Quality control and monitoring will be conducted by Beijing Jishuitan hospital, as well as the centralised image interpretation.

Conditions

Hip Fractures; Osteoporosis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• a:Osteoporotic patients b:Osteoporotic hip fracture patients (femoral neck fracture and femoral trochanteric fracture) c: Be willing to and be able to join in the study and sighed the informed consent

Exclusion Criteria

• a:Under 47years old b:Non-surgical repair of hip fracture c:Pathologic fracture d:Violence-related trauma e:Bilateral hip implants or have hip replacement on the non-fractured side

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Beijing Jishuitan Hospital

OTHER

Sponsor Role: lead

Responsible Party

xiaoguang Cheng

Chairman, Department of Radiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xiaoguang Cheng, MD

Role: PRINCIPAL_INVESTIGATOR

department of radiology, Beijing Jishuitan Hospital

Locations

Beijing ji shui tan hospital

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xiaoguang Cheng, MD

Role: CONTACT

xiao65@263.net

0086-010-58516947

Yongbin Su, MD

Role: CONTACT

dazaiqianyuan@126.com

0086-010-58516688 ext. 6196

Facility Contacts

Xiaoguang Cheng, MD

Role: primary

xiao65@263.net

0086-010-58516947

Ling Wang, MD

Role: backup

1988yisheng@163.com

0086-010-58516688 ext. 6196

References

Ma Y, Ge Y, Guo Z, Su Y, Wang C, Wang Q, Wang L, Cheng X, Yang M, Yan D. Hip structural analysis parameters are not associated with the risk of postmenopausal female second hip fracture: a retrospective study. BMC Musculoskelet Disord. 2025 Mar 10;26(1):233. doi: 10.1186/s12891-025-08368-7.

Reference Type: DERIVED

PMID: 40065296 (View on PubMed)

Other Identifiers

JST2016CSHFE

Identifier Type: -

Identifier Source: org_study_id