Perfusion and Hypoxia Evaluation in Tumors Using 18F-FDG PET/CT

NCT ID: NCT03373994

Last Updated: 2020-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-01

Study Completion Date

2020-12-31

Brief Summary

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Investigators want to use 18F-FDG PET/CT imaging to reflect tumor perfusion and hypoxia.

Detailed Description

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Perfusion and hypoxia were independent prognositic parameters for tumor patients. Developing a method that can evaluate tumor perfusion and hypoxia noninvasively and conveniently was in urgent need. 18F-FDG PET/CT imaging could reflect tumor hypoxia in 60min balanced imaging was proved and accepted. Moreover, FDG could diffuse out of the vasculature and through cell membranes passively and rapidly due to its lipophilicity, its regional uptake at initial times is expected to reflect tumor perfusion. So, investigators want to use 18F-FDG PET/CT imaging to evaluate tumor perfusion and hypoxia simutaniously,in order to guide the clinical diagnosis and treatment.

Conditions

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Perfusion and Hypoxia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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18F-FDG PET/CT initial-time imaging

PET/CT imaging was underwent 5min after 18F-FDG injection.

18F-FDG PET/CT initial-time imaging

Intervention Type DIAGNOSTIC_TEST

18F-FDG intravenous bolus injection after a fasting perid of more than 6 hours, simultaneously,PET/CT imaging using one bed lasting 5 minutes was underwent.

18F-FDG PET/CT balanced-time imaging

PET/CT imaging was underwent 60min after 18F-FDG injection.

18F-FDG PET/CT balanced-time imaging

Intervention Type DIAGNOSTIC_TEST

18F-FDG intravenous injection after a fasting perid of more than 6 hours. After 60 minutes, PET/CT imaging using 6-7 bed positions each lasting 2 minutes was underwent.

Interventions

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18F-FDG PET/CT initial-time imaging

18F-FDG intravenous bolus injection after a fasting perid of more than 6 hours, simultaneously,PET/CT imaging using one bed lasting 5 minutes was underwent.

Intervention Type DIAGNOSTIC_TEST

18F-FDG PET/CT balanced-time imaging

18F-FDG intravenous injection after a fasting perid of more than 6 hours. After 60 minutes, PET/CT imaging using 6-7 bed positions each lasting 2 minutes was underwent.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 1.solid tumor proved by pathology(d\>3.0cm);
* 2.age\>18-year-old;
* 3\. Karnofsky performance status \>70;
* 4.sign the informed consent.

Exclusion Criteria

* 1.There are obvious metal implants near the tumor;
* 2.Can not lie still for 15 minutes.
* 3.Pregnancy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Harbin Medical University

OTHER

Sponsor Role lead

Responsible Party

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Yingying Sun

Attending physician, doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Baozhong Shen, Dr

Role: STUDY_CHAIR

The Fourth Hospital of Harbin Medical University

Locations

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Yingying Sun

Harbin, Heil, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yingying Sun, Dr

Role: CONTACT

13936447513

Facility Contacts

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Yingying Sun, Dr

Role: primary

13936447513

Other Identifiers

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14008

Identifier Type: -

Identifier Source: org_study_id

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