F-18 FDG PET/CT and CT in Initial Staging of Non-small Lung Cancer

NCT ID: NCT06789562

Last Updated: 2025-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

54 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-30

Study Completion Date

2027-12-31

Brief Summary

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Is to compare F-18 FDG PET/CT to routine CT in staging of non-small lung cancer and effect on change management.

Detailed Description

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* The optimal treatment of non-small cell lung cancer (NSCLC) relies on accurate disease staging that is based on the TNM system which relies on tumor size, regional nodal involvement, and the presence of metastasis.
* CT is the standard modality used to assess the intra-thoracic spread but false negative CT scans have been reported and were related to the presence of metastasis in normal sized lymph nodes and false positive findings have been related to lymph node enlargement due to benign process.

PET is most widely used in thoracic oncology because of its superiority over other imaging techniques in staging nodal and metastatic disease, however, the poor anatomic details of PET can lead to errors in diagnosis and staging.

• To solve this problem, CT is combined with PET to provide matched morphological and functional data. The diagnostic capability of PET/CT in the preoperative staging of lung cancer is superior to that of CT alone and PET alone as it has the advantage of a more accurate assignment of tumor stage (T stage) and defining the lymph node stage (N stage) as well as reduction of the number of useless thoracotomies

Conditions

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Lung Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Interventions

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F-18FDG PET/CT and CT

compare F-18 FDG PET/CT to routine CT in staging of non-small lung cancer and effect on change management.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients with pathologically proven NSCLC who underwent initial PET/CT images.
* All patients ≥ 18 years.

Exclusion Criteria

* Patients who had started treatment before initial PET/CT. Patients with glucose level \< 200 mg/dl. Patients with another malignant condition.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Walaa Gamal Fathy

Assistant leacturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Walaa Gamal, assistant lecturer

Role: CONTACT

01065037395

Nahla Moustafa, assistant professor

Role: CONTACT

01009466255

References

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Hadar R, Slonim A, Kuhn J. Role of D-tryptophan oxidase in D-tryptophan utilization by Escherichia coli. J Bacteriol. 1976 Mar;125(3):1096-1104. doi: 10.1128/jb.125.3.1096-1104.1976.

Reference Type BACKGROUND
PMID: 3493 (View on PubMed)

Other Identifiers

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F-18 FDG PET/CTand CT in lung

Identifier Type: -

Identifier Source: org_study_id

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