Exploratory Study of Volatile Organic Compounds in Alveolar Breath

NCT ID: NCT03451994

Last Updated: 2020-10-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

23 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-01

Study Completion Date

2020-10-11

Brief Summary

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The purpose of this secondary analysis is to identify breath signatures associated with idiopathic malodor conditions.

Detailed Description

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Individuals with metabolic disorders may sporadically produce malodors despite good hygiene. Analysis of volatile organic compounds (VOCs) helps to gain insights into medical conditions arising due to metabolic dysfunction as different metabolic pathways emit and or consume various VOCs. These VOCs can be detected via the exhaled breath collected and analyzed with a portable breath collection apparatus. VOC profiles will be compared with self-reported symptoms and other observations of participating subjects.

Conditions

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Nutritional and Metabolic Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Body odor

individuals self-reporting idiopathic body odor with or without bad breath

Breath test

Intervention Type OTHER

Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.

Breath odor

individuals self-reporting idiopathic bad breath but no body odor

Breath test

Intervention Type OTHER

Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.

Interventions

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Breath test

Breath samples taken from all participants, analyzed with gas chromatography mass spectrometry (GC/MS), no treatment given.

Intervention Type OTHER

Other Intervention Names

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Exhaled breath metabolomics

Eligibility Criteria

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Inclusion Criteria

* good general health
* willing and able to travel to one of the participating sites

Exclusion Criteria

* medical conditions that, in the opinion of the investigator, would prevent participation
* elect not to participate in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Menssana Research, Inc.

INDUSTRY

Sponsor Role collaborator

Aurametrix

OTHER

Sponsor Role collaborator

Mebo Research, Inc.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Irene Gabashvili, PhD

Role: PRINCIPAL_INVESTIGATOR

MeBO Research

Locations

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MeBO Research

Miami, Florida, United States

Site Status

MeBO Research LTD

London, England, United Kingdom

Site Status

Countries

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United States United Kingdom

References

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Phillips M. Method for the collection and assay of volatile organic compounds in breath. Anal Biochem. 1997 May 1;247(2):272-8. doi: 10.1006/abio.1997.2069.

Reference Type BACKGROUND
PMID: 9177688 (View on PubMed)

Other Identifiers

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20111001005MEBO

Identifier Type: -

Identifier Source: org_study_id

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