High-flow Nasal Cannula Nebulization of Beta 2 Adrenergic Agonist During Acute Exacerbation of Chronic Obstructive Pulmonary Disease

NCT ID: NCT03449056

Last Updated: 2019-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-11

Study Completion Date

2020-04-30

Brief Summary

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High-flow nasal cannula is an oxygenation technique increasingly used for patients admitted for acute respiratory failure. Literature essentially concerns "de novo" acute hypoxemic failure and the interest of high-flow during take care of chronic obstructive pulmonary disease patients is few studied. Physiological studies reported potential benefits of high-flow nasal cannula oxygenation in chronic obstructive pulmonary disease patients including dead space clearance and decrease of respiratory, which lead to decrease work of breathing. As inhaled bronchodilators are part of treatment of chronic obstructive pulmonary disease exacerbation, nebulization could be also provided through high-flow nasal cannula oxygen therapy. The aim of our study is to determine whether a beta-2 agonist nebulization administered through High-flow nasal cannula is efficient to improve spirometry of patients for admitted hronic obstructive pulmonary disease exacerbation.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease High-flow Nasal Cannula

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TREATMENT

salbutamol nebulization

Group Type EXPERIMENTAL

salbutamol

Intervention Type DRUG

T2 - T1+1h30: High-nasal flow and salbutamol nebulization

Interventions

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salbutamol

T2 - T1+1h30: High-nasal flow and salbutamol nebulization

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Arterial pH over 7.25,
* Respiratory rate under 35 breaths/mn
* Glasgow Coma Scale equal to 15,
* indication of beta-2 agonist nebulization less than 8 per day (time between two nebulization more than 3 hours),
* NIV sessions spaced more than 6 hours.

Exclusion Criteria

* Urgent endotracheal intubation;
* Contraindication to beta 2 adrenergic agonist;
* Another organ failure (hemodynamic and neurological instability);
* Cardioselective beta-blocker during treatment of copd exacerbation;
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Poitiers University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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C.H.U. de Poitiers

Poitiers, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Jean-Pierre FRAT

Role: CONTACT

+33549442830

nicolas MARJANOVIC

Role: CONTACT

Facility Contacts

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Jean-Pierre Frat, MD

Role: primary

Other Identifiers

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OPTINEB

Identifier Type: -

Identifier Source: org_study_id

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