Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
177 participants
OBSERVATIONAL
2018-09-03
2020-04-03
Brief Summary
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Detailed Description
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The investigators will detect retinal signals as electrical messages. Sensors placed near the eye pick up the electrical changes in the retina each time a light flashes. This non-invasive, routine clinical test is called an electroretinogram, (ERG). The investigators have carried out a study that showed differences in the ERGs recorded from adults with ASD compared to control participants.
The main aim of this project is find out how common ERG differences are in children with ASD compared to controls. If it is common, investigators could use the ERG to make an earlier diagnosis of ASD and help families sooner. It could help investigators better understand the way the ASD brain signals and give investigators a way of measuring if therapies work.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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autistic spectrum disorder
intelligence quotient IQ\>85 age 4-25yrs
electroretinogram (ERG)
an ERG is a measure of the eyes response to a flash of light
control
age 4-25yrs no eye disorder
electroretinogram (ERG)
an ERG is a measure of the eyes response to a flash of light
Interventions
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electroretinogram (ERG)
an ERG is a measure of the eyes response to a flash of light
Eligibility Criteria
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Inclusion Criteria
* cohort 2: typically developed controls without diagnosis of ASD
Exclusion Criteria
4 Years
25 Years
ALL
Yes
Sponsors
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Flinders University
OTHER
Yale University
OTHER
Swinburne University of Technology
OTHER
Great Ormond Street Hospital for Children NHS Foundation Trust
OTHER
Responsible Party
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Principal Investigators
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Dorothy A Thompson, PhD
Role: PRINCIPAL_INVESTIGATOR
Consultant Clinical Scientist Visual Electrophysiology, Great Ormond Street Hospital for Children London UK
Paul Constable, PhD
Role: STUDY_DIRECTOR
Head Of Teaching Optometry, Flinders Vision Autism Centre, Flinders University, Australia
James McPartland, PhD
Role: PRINCIPAL_INVESTIGATOR
Associate Professor of Child Psychiatry and Psychology, Director, Yale Developmental Disabilities Clinic, Yale University, USA
Locations
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Yale University
New Haven, Connecticut, United States
Flinders University
Adelaide, South Australia, Australia
Swinburne University of Technology
Melbourne, , Australia
Great Ormond Street Hospital for Children NHS Trust
London, , United Kingdom
Countries
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Other Identifiers
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17PP33
Identifier Type: -
Identifier Source: org_study_id
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