Development of Eye-tracking Based Markers for Autism in Young Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-09

Study Completion Date

2018-02-28

Brief Summary

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The main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (ASD). To this end a battery of five eye-tracking paradigms will be administered to young children with ASD and typically developing children. To additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than ASD will be included.

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Detailed Description

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During an initial screening session all participants will undergo the Autism Diagnostic Observation Schedule (ADOS). ASD-related symptomatology and levels of impairments will be further characterized using the Social Responsibilities Scale 2 (SRS 2), Caregiver Strain Questionnaire (CSQ), Aberrant Behavior Checklist (ABC), Social Communication Questionnaire (SCQ), and Repetitive Behaviour Scale Revised (RBS-R).

Subsequently all participants will be administered the following eye-tracking paradigms: (1) dynamic social and non-social visual preference paradigm during which dynamic geometric images (DGI) and dynamic social images (DSI) will be presented, (2) non-biological versus biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4) preference for real versus schematic emotional face stimuli paradigm during which photographs of human faces and emoticons will be presented, (5) shared social attention and gaze direction paradigm.

Conditions

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Autism Spectrum Disorder

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Children with Autism Spectrum Disorder

Children with an Autism Spectrum Disorder according to DSM-5 criteria

Administration of five eye-tracking paradigms

Intervention Type OTHER

All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Typically Developing Children

Typically developing children

Administration of five eye-tracking paradigms

Intervention Type OTHER

All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Children with Delayed Development Disorders

Children with Delayed Developmental Disorders other than ASD

Administration of five eye-tracking paradigms

Intervention Type OTHER

All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Interventions

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Administration of five eye-tracking paradigms

All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* written informed consent from parents / caregiver
* age: 1-10 years

Additional inclusion criterion for the ASD group:

\- diagnosis of Autism Spectrum Disorder according to DSM-5

* no symptoms of developmental disorders
* no current or history of psychological disorder

Additional inclusion criterion for the unspecific disorder of delayed development children in the additional control group:

\- disorder of delayed development other than ASD