Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study
NCT ID: NCT02807766
Last Updated: 2024-01-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
150 participants
INTERVENTIONAL
2016-05-31
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
BASIC_SCIENCE
TRIPLE
Study Groups
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Sensory Integration Training
Behavior modification and Sensory Integration Training
Behavior modification and sensory integration training
Each group has 30 subjects and experiences six months' training.
applied behavioral analysis
Behavior modification and applied behavioral analysis.
Behavior modification and applied behavioral analysis
Each group has 30 subjects and experiences six months' training.
TEACCH
Behavior modification and TEACCH.
Behavior modification and TEACCH
Each group has 30 subjects and experiences six months' training.
Behavior modification
Behavior modification.
Behavior modification
Each group has 30 subjects and experiences six months' training.
healthy control group
No intervention.
No interventions assigned to this group
Interventions
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Behavior modification
Each group has 30 subjects and experiences six months' training.
Behavior modification and sensory integration training
Each group has 30 subjects and experiences six months' training.
Behavior modification and applied behavioral analysis
Each group has 30 subjects and experiences six months' training.
Behavior modification and TEACCH
Each group has 30 subjects and experiences six months' training.
Eligibility Criteria
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Inclusion Criteria
* Clinical DSM-IV diagnosis of autism.
Exclusion Criteria
* Subjects with contraindications to MRI.
2 Years
8 Years
ALL
Yes
Sponsors
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University of Electronic Science and Technology of China
OTHER
Responsible Party
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Huafu Chen
professor
Principal Investigators
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Huafu Chen
Role: PRINCIPAL_INVESTIGATOR
School of Life Science and Technology, University of Electronic Science and Technology of China
Locations
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Department of Children's and Adolescent Health, Public Health College of Harbin Medical University
Harbin, Heilongjiang, China
Center for Information in BioMedicine, Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China
Chengdu, Sichuan, China
Countries
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Central Contacts
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Facility Contacts
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References
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Huang X, Ming Y, Zhao W, Feng R, Zhou Y, Wu L, Wang J, Xiao J, Li L, Shan X, Cao J, Kang X, Chen H, Duan X. Developmental prediction modeling based on diffusion tensor imaging uncovering age-dependent heterogeneity in early childhood autistic brain. Mol Autism. 2023 Oct 30;14(1):41. doi: 10.1186/s13229-023-00573-2.
Guo X, Duan X, Suckling J, Wang J, Kang X, Chen H, Biswal BB, Cao J, He C, Xiao J, Huang X, Wang R, Han S, Fan YS, Guo J, Zhao J, Wu L, Chen H. Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain. Cereb Cortex. 2021 Feb 5;31(3):1500-1510. doi: 10.1093/cercor/bhaa304.
Other Identifiers
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UESTC-chenhuafulab-001
Identifier Type: -
Identifier Source: org_study_id
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