Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol
NCT ID: NCT03393728
Last Updated: 2018-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE4
10 participants
INTERVENTIONAL
2008-09-01
2009-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).
Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Analysis of Atropine and Propranolol Induced Changes
NCT00251602
Perioperative Effect of Atenolol on Cytokine Profiles
NCT00202358
Ivabradine Versus Propranolol for Induced Hypotension in Endoscopic Sinus Surgery
NCT04580342
A Study of Lasmiditan and Propranolol in Healthy Participants
NCT03270644
A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State
NCT03882255
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).
Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.
The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Intervention
72-hour propanolol before specific treatment of hyperthyroidism
Propanolol
72-hour propanolol before specific treatment of hyperthyroidism
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Propanolol
72-hour propanolol before specific treatment of hyperthyroidism
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* naïve of all treatment specific for hyperthyroidism.
* aged 18-70 years
Exclusion Criteria
* Patients taking beta blockers or any other cardiospecific treatment
* Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure
* Contraindications to the prescription of beta blockers
18 Years
70 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Yaounde Central Hospital
OTHER_GOV
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Sobngwi Eugene
Professor of Endocrinology and Metabolism
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Jean Claude N Mbanya, MD, PhD
Role: STUDY_CHAIR
Yaounde Central Hospital and University of Yaounde 1
Eugène Sobngwi
Role: PRINCIPAL_INVESTIGATOR
Hôpital Central de Yaoundé et Université de Yaoundé 1
References
Explore related publications, articles, or registry entries linked to this study.
Tankeu AT, Azabji-Kenfack M, Nganou CN, Ngassam E, Kuate-Mfeukeu L, Mba C, Dehayem MY, Mbanya JC, Sobngwi E. Effect of propranolol on heart rate variability in hyperthyroidism. BMC Res Notes. 2018 Feb 22;11(1):151. doi: 10.1186/s13104-018-3224-x.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
YaoundeCH
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.