co2 Gap and co2/o2 Ratio in Liver Transplant Patients

NCT ID: NCT03374579

Last Updated: 2018-03-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-12

Study Completion Date

2018-09-12

Brief Summary

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finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Detailed Description

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use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.

Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

Conditions

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Liver Transplantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Fluid challenge with assessment of change of co2 gap
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CO2 gap

The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.

Group Type EXPERIMENTAL

Fluid challenge

Intervention Type DIAGNOSTIC_TEST

Fluid challenge and measure change in co2 gap

Interventions

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Fluid challenge

Fluid challenge and measure change in co2 gap

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patients post liver transplantation
* serum lactate \>2mmol/L

Exclusion Criteria

* age less than 18 years
* patients with fulminant liver failure.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kasr El Aini Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ahmed Mukhtar

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ahmed m Mukhtar, professor

Role: PRINCIPAL_INVESTIGATOR

kasrelainy medical school,cairo university,cairo,egypt

Hassan kh Nagi, professor

Role: STUDY_CHAIR

kasrelainy medical school,cairo university,cairo,egypt

Locations

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Cairo University Medical School

Cairo, , Egypt

Site Status RECRUITING

Kasralainy hospital

Cairo, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Ahmed m Mukhtar, Professor

Role: CONTACT

+0220111420844

Hassan kh Nagi, Professor

Role: CONTACT

01223634792

Facility Contacts

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Ahmed m Mukhtar, professor

Role: primary

01114208444 ext. 002

Hassan kh Nagy, professor

Role: backup

01223634792 ext. 002

Ahmed Mukhtar, Professor

Role: primary

01114208444

Hassan Khaled, Professor

Role: backup

01223634792

Other Identifiers

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N-60-2017

Identifier Type: -

Identifier Source: org_study_id

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