Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-01

Study Completion Date

2019-03-08

Brief Summary

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Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a vascular remodelling named athlete's artery. Moreover, the investigators know that left ventricle and aorta behave together like a couple. So they want to study by Cardiovascular Magnetic Resonance Imaging the impact of triathlon on the cardiac AND aortic remodelling.

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Detailed Description

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Conditions

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Stiffness, Aortic Cardiac Remodeling, Ventricular Vascular Remodeling Magnetic Resonance Imaging, Functional Athletes

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Triathletes

Every triathlete will realize three cardiac MRI exams.The second of those will be done at the fitness peak, 2-3 weeks before the main objective of the sports season. Training will be increased between the study beginning and the first MRI, and the second exam. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Group Type EXPERIMENTAL

Cardiac MRI

Intervention Type DEVICE

Non injected cardiac MRI exam

Applanation tonometry

Intervention Type DEVICE

Applanation tonometry and ECG

Controls

Every control subject will also realize three cardiac MRI exams if possible at the same time as the triathletes.They must be not engaged in physical activity more than 150 minutes a week on average. After each cardiac MRI, an applanation tonometry examination will aslo be performed.

Group Type EXPERIMENTAL

Cardiac MRI

Intervention Type DEVICE

Non injected cardiac MRI exam

Applanation tonometry

Intervention Type DEVICE

Applanation tonometry and ECG

Interventions

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Cardiac MRI

Non injected cardiac MRI exam

Intervention Type DEVICE

Applanation tonometry

Applanation tonometry and ECG

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* to be enrolled in a social security plan.
* to have a BMI between 18,5 and 25 kg/m²
* to have received full information on the organization of the research and having signed its informed consent
* to have carried out a clinical screening adapted to the research

\*\*\* Triathlete group:
* to have a minimum performance level: between 2h and 2h45 on an M triathlon during the past year (provide proof),
* to participate in 2018 in a long distance triathlon, i. e. at least distance L
* to have a defined training volume: less than 8 hours per week during the winter months and between 10 and 15 hours per week in preparation of the objective

\*\*\*Control group:
* to have no more than 150 minutes of moderate physical activity per week (footing, brisk walking, cycling, etc.).

Exclusion Criteria

* Persons referred to in Articles L. 1121-5 to L. 1121-8 and L1122-2 of the Public Health Code
* Cardiovascular history including Ii.e. known heart rhythm disorders
* Chronic disease: diabetes, high blood pressure...
* Long-term drug therapies that may modify cardiovascular remodeling such as Conversion Enzyme Inhibitor, Angiotensin II Receptor Antagonist,
* Active smoking, even if occasional
* Contraindication to MRI

Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes