Evaluation of the Predictors of Clinical and Radiological Response to Gamma-Knife Radiosurgery in the Treatment of Intermediate Ventral Nucleus of the Thalamus (VIM) Thalamotomy Tremor.

NCT ID: NCT03350139

Last Updated: 2017-11-22

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 700 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-10-23
• Study Completion Date: 2021-10-22

Brief Summary

Gamma-Knife radiosurgery of the VIM for patients presenting with severe drug-resistant tremor is now current practice as an alternative to Deep Brain Stimulation (DBS) of the VIM.

Now, around 100 patients are treated annually in our unit (essential tremor or Parkinson tremor).

Clinical and radiological follow-up is demonstrating that 80% of these patients are presenting with a homogenous response complete or subtotal, the disappearance of the tremor mean delay of 6 months after radiosurgery. In neuroradiological responses on the MRI, is appearing roughly at the same time local contrast enhancement surrounding highty to signal no associated with clinical side effects.

In 15 to 20% of the patients, the clinical effets is not obtained and in the vast majority no MRI response or minimal MRI response is observed on images suggesting that these failures are related to specific resistance to radiosurgery of this subgroup.

In roughly 5% of the patients, at the contrary, hyper response is observe on the MRI rating clinically with side effects (hemiparesis or proprioceptive ataxia or dysarthria, hands problems….). The adverse effects are generally reversible either in whole or in part with the resorption of the perilesionnel oedema.

It would be extremely helpfull to be able to identify in advance these 2 groups of hyper and hypo respondeurs.

The capacity to identify in advance these patients at risk to hypo or hyper response would allow us to either contre-indicate radiosurgery or modify radiosurgery technicaly at the time of dose planing.

Sequently, these predictions would allow us to tailor individually mission management and information leading to improvment of the efficacy and tolerance of this kind of intervention.

The parameters suspected to be likely to influence the response are :

• genetics
• co-morbidities (diabetis, vascular…)
• Main aspect of the brain (severe atrophy, vascular, micro-infacts…)
• Chronobiological (timing during the day of the radiosurgical procedure)
• Associated medication (potential radioprotector or radiosensitizer effect of some drugs)
• Radiobiological (dose rate…)

The goal of this study is to collect all of these informations out of genetical one in the cohort of 700 patients having benefited ou will benefit from radiosurgery in the situation for essential tremor and parkinson disease. It will be test the predictive value of these parameters and the capacity to predict hyper or hypo response.

The work on the genetic material will take place in the second stage in the frame of a new different resarch project.

Conditions

Severe Disabling Tremor

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients treated with gamma knife radiosurgery

Collection of non-genetic, chronobiological, therapeutic and co-morbidities

gamma knife radiosurgery

Intervention Type: DEVICE

The surgical procedure consists of a very partial radiation of the brain with a stereotactic precision performed in current practice

Interventions

gamma knife radiosurgery

The surgical procedure consists of a very partial radiation of the brain with a stereotactic precision performed in current practice

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Male or female aged 20 years minimum
• Patient with absolute contraindication or relative to deep brain stimulation (DBS) of VIM.
• Patient having the Gamma Knife radiosurgery of VIM (combining clinical and paraclinical conditions).
• Patient affiliated to a social security scheme.
• Patient having understood and signed the information notice for non opposition.

Exclusion Criteria

• Patient having a contraindication to performing a cerebral MRI (pace-maker, intracerebral metallic object etc.)
• Patient with a contraindication to radiosurgical treatment (previous treatment with cerebral radiotherapy)
• Vulnerable persons: minors, protected adults (guardianship or trusteeship) and adults unable to express their non-opposition.

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique Hopitaux De Marseille

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jean-Olivier ARNAUD, General Director

Role: STUDY_DIRECTOR

Assistance Publique Hôpitaux de Marseille

Locations

Assistance Publique Hôpitaux de Marseille

Marseille, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Jean REGIS, PU-PH

Role: CONTACT

Phone: 491387058

Email: jregis@ap-hm.fr

Facility Contacts

Jean REGIS, PU-PH

Role: primary

Other Identifiers

ID RCB

Identifier Type: REGISTRY

Identifier Source: secondary_id

2017-09

Identifier Type: -

Identifier Source: org_study_id