Study of Adaptive Radiotherapy for High-grade Glioma Based on Interfraction MRI

NCT ID: NCT06201351

Last Updated: 2024-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2026-09-30

Brief Summary

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The changes of target and organs at risk in patients with high-grade glioma during concurrent chemoradiotherapy were evaluated by MRI image between radiotherapy fractions.

Detailed Description

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To prospectively evaluate the changes of target organs and risk organs in patients with high-grade glioma during concurrent chemoradiotherapy.The related factors causing this change are discussed.The relationship between changes and patient survival was analyzed.A predictive model was established to provide individualized adaptive radiotherapy for patients.

Conditions

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High-grade Glioma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Adaptive radiotherapy group

MRI was performed and adaptive radiotherapy was administered at farction10 and fraction 20 during radiotherapy.

adaptive radiotherapy

Intervention Type DEVICE

MRI was performed and adaptive radiotherapy was administered at farction10 and fraction 20 during radiotherapy.

Interventions

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adaptive radiotherapy

MRI was performed and adaptive radiotherapy was administered at farction10 and fraction 20 during radiotherapy.

Intervention Type DEVICE

Other Intervention Names

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ART

Eligibility Criteria

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Inclusion Criteria

1. Age ≥18 years old;
2. High-grade glioma was confirmed by pathology after surgery;
3. ECOG score 0-2 points;
4. Receiving the standard STUPP regimen (i.e. 6 weeks of temozolomide concurrent chemoradiotherapy +6 cycles of temozolomide adjuvant chemotherapy);
5. Baseline data available.

Exclusion Criteria

1. The pathological diagnosis is not clear;
2. No synchronous chemotherapy/adjuvant chemotherapy \< 6 cycles;
3. There are other malignant tumors;
4. Previously radiotherapy to the head;
5. Interruption of radiotherapy for more than 5 days;
6. Failure to collect baseline data.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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West China Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ping Ai

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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West China Hospital

Chengdu, Sichuan, China

Site Status

Countries

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China

Central Contacts

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Ping Ai, MD

Role: CONTACT

18980602055

Shuangshuang He

Role: CONTACT

18708178816

Facility Contacts

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Biomedical Ethics Review Committee, West China Hospital

Role: primary

8685423237

Other Identifiers

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Trial No. 1460, 2023

Identifier Type: -

Identifier Source: org_study_id

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