Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28551 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2012-12-31

Brief Summary

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Vitamin D deficiency is a modifiable risk factor for poor bone health. Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs. However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations. In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort. Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring. Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.

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Detailed Description

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From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families. The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method. Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.

Conditions

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Vitamin D Deficiency

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

RETROSPECTIVE

Study Groups

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Vitamin D deficiency

serum 25(OH)D \< 30 nmol/L

No interventions assigned to this group

Vitamin D insufficiency

serum 25(OH)D between 30 and 49 nmol/L

No interventions assigned to this group

Vitamin D sufficiency

serum 25(OH)D ≥ 50 nmol/L

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants

Exclusion Criteria

* missing value on 25-hydroxyvitamin D levels
* data on another household member was unavailable
* the precise family relationship between the subjects was unclear

Minimum Eligible Age

10 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes