Reducing Surgical Site Infection Rates Using an Alternative Sternal Dressing

NCT ID: NCT03346694

Last Updated: 2022-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

660 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2035-05-01

Brief Summary

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This study will evaluate two alternative dressings compared to a standard Island dressing presently in use at Stanford Hospital to determine reductions in surgical site infection (SSI) rates among cardiac surgery patients. Cardiovascular surgery patients who will have a sternotomy incision as a routine part of their surgery will be approached to voluntarily participate. Participants will be randomized to one of three dressing to determine which dressing has the lowest rate of sternal wound infection. The investigators will also assess the impact of alternative dressing use on hospital 30-day readmission rates related to SSI.

Detailed Description

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Conditions

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Wound of Skin

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participant randomly assigned to either a control or one of two intervention groups
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Dressing 1: Standard Island Dressing

Standard dressing that is applied on most patients with a sternotomy wound incision immediately after cardiovascular surgery before leaving the operating room. Dressing will be removed 48 hours after surgery.

Group Type ACTIVE_COMPARATOR

Standard Island Dressing

Intervention Type DEVICE

participant randomized to control group before end of surgery to be applied on cardiovascular heart surgical sternal incision.

Dressing 2: Prevena negative pressure

Prevena negative pressure wound suction machine dressing applied to sternotomy wound incision immediately after cardiovascular surgery. Dressing will be in use for 7 days or removed sooner if participant is discharged before end of 7 day post-operative time period.

Group Type ACTIVE_COMPARATOR

Prevena Negative Pressure wound dressing

Intervention Type DEVICE

participant randomized to dressing before end of surgery to be applied on cardiovascular heart surgical sternal incision.

Dressing 3: Mepilex Border Post-Op Ag

Mepilex Border PostOp AG dressing impregnated with silver ions. Dressing will be in use for 7 days or removed earlier if patient is discharged before end of 7 days post0operative time period.

Group Type ACTIVE_COMPARATOR

Mepilex Border Post-Op Ag

Intervention Type DEVICE

Participant randomized to dressing before end of surgery to be applied on cardiovascular heart surgical sternal incision

Interventions

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Standard Island Dressing

participant randomized to control group before end of surgery to be applied on cardiovascular heart surgical sternal incision.

Intervention Type DEVICE

Prevena Negative Pressure wound dressing

participant randomized to dressing before end of surgery to be applied on cardiovascular heart surgical sternal incision.

Intervention Type DEVICE

Mepilex Border Post-Op Ag

Participant randomized to dressing before end of surgery to be applied on cardiovascular heart surgical sternal incision

Intervention Type DEVICE

Other Intervention Names

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Dressing 1 Dressing 2 Dressing 3

Eligibility Criteria

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Exclusion Criteria

* Patients undergoing heart transplants, Ventricular Assist Device (VAD), with postoperative courses complicated by tamponade, take-backs, and open chest incisions will also be excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Jack Boyd

Prinicipal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jack Boyd, M.D.

Role: PRINCIPAL_INVESTIGATOR

Cardiovascular Surgeon

Locations

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Stanford Healthcare

Stanford, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Jack Boyd, M.D.

Role: CONTACT

650-736-2042

Clarivil Cruz Gonzales, RN

Role: CONTACT

650-542-6532

References

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Lwanga, S.K. & Lemeshow, S. (1991). Sample size determination in health studies: a practical manual. World Health Organization: Geneva, Switzerland.

Reference Type BACKGROUND

R Core Team (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.

Reference Type BACKGROUND

Barnes S. What's new in SSI prevention? AORN J. 2015 Jun;101(6):P10-2. doi: 10.1016/s0001-2092(15)00421-4. No abstract available.

Reference Type RESULT
PMID: 26219113 (View on PubMed)

Ly, E. (2015). Cardiothoracic (CT) surgery data summary- all surgical site infections by quarter 2015 [PowerPoint slides]. Retrieved from personal communication.

Reference Type RESULT

Kles CL, Murrah CP, Smith K, Baugus-Wellmeier E, Hurry T, Morris CD. Achieving and Sustaining Zero: Preventing Surgical Site Infections After Isolated Coronary Artery Bypass With Saphenous Vein Harvest Site Through Implementation of a Staff-Driven Quality Improvement Process. Dimens Crit Care Nurs. 2015 Sep-Oct;34(5):265-72. doi: 10.1097/DCC.0000000000000131.

Reference Type RESULT
PMID: 26244240 (View on PubMed)

Related Links

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https://www.R-project.org/

A Language and environment for statistical computing

Other Identifiers

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41985

Identifier Type: -

Identifier Source: org_study_id

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