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Preoperative Vitamin D Levels and Respiratory Complications of General Anesthesia

NCT ID: NCT03342651

Last Updated: 2017-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

95 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-01

Study Completion Date

2016-12-31

Brief Summary

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Vitamin D deficiency is a commonly observed health problem in the world. With a role in many chronic diseases and especially lung diseases, the importance of vitamin D deficiency in anesthesia management is increased. This research aims to investigate whether there is a correlation between the respiratory complications occurring in patients under general anesthesia and preoperative vitamin D levels.

Detailed Description

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This study included 95 adult cases aged from 18-65 years operated under general anesthesia. The cases had total 25-hydroxyvitamin D (25OHD) levels identified in blood samples before the operation. Patients given routine general anesthesia and postoperative monitoring procedures were assessed in terms of respiratory complications during anesthesia induction, extubation, anesthesia recovery and the first 24 hours postoperative.

This research observed that patients with low preoperative 25OHD vitamin levels encountered respiratory complications related to general anesthesia more often. Especially in the early postoperative period there is a very significant difference between complications and low 25OHD vitamin levels. Our study results show that low vitamin D levels may be a potential risk in terms of respiratory complications related to general anesthesia causing severe morbidity and mortality increase. The results lead to the consideration that optimizing vitamin D levels in the preoperative period for patients undergoing general anesthesia may aid in reducing complications.

Conditions

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Vitamin D Deficiency

Keywords

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Vitamin D general anesthesia respiratory complications

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Observational research

Vitamin D levels and respiratory complications; observational research.

Group Type OTHER

Vitamin D

Intervention Type OTHER

Vitamin D, general anesthesia, respiratory complications

Interventions

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Vitamin D

Vitamin D, general anesthesia, respiratory complications

Intervention Type OTHER

Other Intervention Names

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Anesthesia, respiratory complications

Eligibility Criteria

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Inclusion Criteria

\- American Society of Anesthesiologists I - II risk classification, healthy adult surgery cases

Exclusion Criteria

* Thoracic surgery, those with severe respiratory, neuromuscular or endocrine system diseases, those with difficult intubation, morbid obesity, using vitamin D supplements and those who smoked
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ordu University

OTHER

Sponsor Role lead

Responsible Party

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Nilay Tas

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nilay Taş, Assoc.Prof.

Role: PRINCIPAL_INVESTIGATOR

Ordu University, Turkey

Tevfik Noyan, Prof.

Role: STUDY_CHAIR

Ordu University, Turkey

Özgür Yağan, Assoc. Prof.

Role: STUDY_CHAIR

Ordu University, Turkey

Volkan Hancı, Prof.

Role: STUDY_CHAIR

Ordu University, Turkey

Ebru Çanakçı, Ass. Prof.

Role: STUDY_CHAIR

Ordu University, Turkey

References

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Hutchinson K, Healy M, Crowley V, Louw M, Rochev Y. Verification of Abbott 25-OH-vitamin D assay on the architect system. Pract Lab Med. 2017 Jan 17;7:27-35. doi: 10.1016/j.plabm.2017.01.001. eCollection 2017 Apr.

Reference Type RESULT
PMID: 28856215 (View on PubMed)

Turan A, Hesler BD, You J, Saager L, Grady M, Komatsu R, Kurz A, Sessler DI. The association of serum vitamin D concentration with serious complications after noncardiac surgery. Anesth Analg. 2014 Sep;119(3):603-612. doi: 10.1213/ANE.0000000000000096.

Reference Type RESULT
PMID: 25121616 (View on PubMed)

Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. doi: 10.1093/ajcn/87.4.1080S.

Reference Type RESULT
PMID: 18400738 (View on PubMed)

Bener A, Ehlayel MS, Bener HZ, Hamid Q. The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem. J Family Community Med. 2014 Sep;21(3):154-61. doi: 10.4103/2230-8229.142967.

Reference Type RESULT
PMID: 25374465 (View on PubMed)

Columbo M, Panettieri RA Jr, Rohr AS. Asthma in the elderly: a study of the role of vitamin D. Allergy Asthma Clin Immunol. 2014 Sep 5;10(1):48. doi: 10.1186/1710-1492-10-48. eCollection 2014.

Reference Type RESULT
PMID: 25221606 (View on PubMed)

Banerjee A, Panettieri R Jr. Vitamin D modulates airway smooth muscle function in COPD. Curr Opin Pharmacol. 2012 Jun;12(3):266-74. doi: 10.1016/j.coph.2012.01.014. Epub 2012 Feb 25.

Reference Type RESULT
PMID: 22365730 (View on PubMed)

Quraishi SA, Camargo CA Jr. Vitamin D in acute stress and critical illness. Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):625-34. doi: 10.1097/MCO.0b013e328358fc2b.

Reference Type RESULT
PMID: 23075939 (View on PubMed)

Mulligan JK, Nagel W, O'Connell BP, Wentzel J, Atkinson C, Schlosser RJ. Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2014 Aug;134(2):342-9. doi: 10.1016/j.jaci.2014.01.039. Epub 2014 Mar 31.

Reference Type RESULT
PMID: 24698317 (View on PubMed)

Ginde AA, Mansbach JM, Camargo CA Jr. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthma Rep. 2009 Jan;9(1):81-7. doi: 10.1007/s11882-009-0012-7.

Reference Type RESULT
PMID: 19063829 (View on PubMed)

Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J Laryngol Otol. 2010 May;124(5):465-9. doi: 10.1017/S0022215109992684. Epub 2010 Jan 13.

Reference Type RESULT
PMID: 20067648 (View on PubMed)

Other Identifiers

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DVIT1

Identifier Type: -

Identifier Source: org_study_id