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Cord Blood 25(oh)-Vitamin D Level in Preterm Infants and Associated Morbidities

NCT ID: NCT01812681

Last Updated: 2014-08-15

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

81 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2013-11-30

Brief Summary

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Experimental and observational studies have shown that vitamin D deficiency may be associated with an increased risk for non-bone diseases and/or abnormal development for the other systems of fetus. The aim of this study is to determine the relationship between cord blood 25-hydroxyvitamin D (25 (OH) D) concentrations and the subsequent risk of morbidities including RDS, PDA, NEC, BPD AND ROP in preterm infants.

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Detailed Description

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It was shown that vitamin D play important role in the pathogenesis of long term morbidities of newborn. Experimental and observational studies have shown that vitamin D deficiency may be associated with an increased risk for non-bone diseases and/or abnormal development for the other systems of fetus. The aim of this study is to determine the relationship between cord blood 25-hydroxyvitamin D (25 (OH) D) concentrations and the subsequent risk of morbidities including RDS, PDA, NEC, BPD AND ROP in preterm infants.

Conditions

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Respiratory Distress Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Low vitamin D level

The premature infants with low cord blood vitamin D level

No interventions assigned to this group

Normal Vitamin D

The premature infants with normal vitamin D level

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* infants \<32 weeks of gestational age

Exclusion Criteria

* infants with major congenital abnormality
* infants \>32 weeks of gestational age
Minimum Eligible Age

1 Day

Maximum Eligible Age

5 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr. Sami Ulus Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Serdar Beken

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dilek Dilli, Assoc Prof

Role: STUDY_DIRECTOR

Sami Ulus CH

Locations

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Sami Ulus CH

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Grant WB. Vitamin D supplementation of mother and infant could reduce risk of sepsis in premature infants. Early Hum Dev. 2010 Feb;86(2):133. doi: 10.1016/j.earlhumdev.2010.02.003. Epub 2010 Feb 25. No abstract available.

Reference Type BACKGROUND
PMID: 20188500 (View on PubMed)

Fettah ND, Zenciroglu A, Dilli D, Beken S, Okumus N. Is higher 25-hydroxyvitamin D level preventive for respiratory distress syndrome in preterm infants? Am J Perinatol. 2015 Feb;32(3):247-50. doi: 10.1055/s-0034-1383849. Epub 2014 Sep 13.

Reference Type DERIVED
PMID: 25217734 (View on PubMed)

Other Identifiers

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B.10.4.İSM.4.06.68.49

Identifier Type: OTHER

Identifier Source: secondary_id

B.10.4.İSM.4.06.68.49

Identifier Type: -

Identifier Source: org_study_id

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