Effect of Need to Void on Parkinsonian Gait

NCT ID: NCT03314610

Last Updated: 2019-09-25

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 11 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-10-16
• Study Completion Date: 2017-12-30

Brief Summary

This study evaluates the effect of the need to void on parkinsonian gait

Detailed Description

Parkinsonian syndromes are common causes of gait disorders, associated with hypometria, bradykinesia or rigidity. If motor disorders are the most visible part, lower urinary tract dysfunction is one of the most prevalent dysautonomic disorder (27-80%), especially over active bladder syndrome (OAB). If it seems evident that gait and urinary disorders are linked, because of similar anatomic pathways and control processes, no studies have investigated their association in extrapyramidal patients.

The aim of this study is to assess the effect of the need to void on the walking speed in this particular population.

This prospective study inclues all parkinsonian syndromes who had a follow-up for OAB. They must have a security delay over five minutes, no severe cognitive, motor or psychiatric disorders. We invite them to drink until a need to void (or equivalent). Bladder filling is measured by bladder scan, then they performe gait tests in a specific place, with calm and no passage : Patient can use their habitual walking device. Speed walk asking is comfortable for the two test. Three ten-meter tests, one double-task ten-meter test, one timed-up-and-go test, one timed raise of the floor (GMT). We repeat the same tests after voiding or self-catheterization. Toilets are just next to the hall where they realize the tests. A clinical examination assesses urinary dysfunction (USP, IPSS), motor score (UPDRS-III, Hoehn and Yahr scale, daily equivalent of levodopa), history of falls and comorbidities.

Conditions

Lower Urinary Tract Symptoms; Parkinsonism; Gait Disorders, Neurologic

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients enrolled

Patient with parkinsonian syndromes and lower urinary tract symptoms, age \> 18, able to walk without human help on 50 meters, able to hold urine at least 3 minutes. A first record of gait speed will be at strong desire to void. A second record will be after voiding or catheterization Gait records consist on : 3x 10 meter walk test, 1x double task 10 meter walk test, 1x Timed up and Go test and 1x GMT

Gait speed

Intervention Type: OTHER

No intervention, only propose water and wait for need to void

Interventions

Gait speed

No intervention, only propose water and wait for need to void

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Parkinsonian syndromes
• Follow in neurourology for Lower urinary tract symptoms
• Able to walk 50 meters without human assistance
• able to hold voiding for more than 3 minutes

Exclusion Criteria

• Actual urinary tract infection
• Montreal cognitive assessment < 20/30
• Acute psychiatric or neurologic disorders who can interfer with walking tests

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pierre and Marie Curie University

OTHER

Sponsor Role: lead

Responsible Party

Gérard Amarenco

Head of Neuro-Urology Department, Tenon Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Gérard Amarenco, PhD

Role: PRINCIPAL_INVESTIGATOR

GREEN GRC-01, Neuro-urology, hôpital Tenon

Locations

Service de Neuro-urology, hôpital Tenon

Paris, , France

Countries

France

Other Identifiers

P. GREEN 001

Identifier Type: -

Identifier Source: org_study_id