Determination of Risk Factors and Mortality for Pediatric Chronic Critical Illness in Turkey

NCT ID: NCT03308513

Last Updated: 2020-09-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 888 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-11-01
• Study Completion Date: 2018-10-31

Brief Summary

It is predicted that the number of Pediatric Chronic Critical Illness increases similar to adult all over the world. The prevalence of Pediatric Chronic Critical Illness in Turkey is unknown. The investigators aimed to evaluate the etiology, comorbid conditions, demographic data, prevalence, mortality and costs of these patient in intensive care units in Turkey. In this multi-centered study, The investigators will retrospectively review the last 3 year of patients receiving treatment at the Intensive Care Unit.

Detailed Description

Patients receiving acute critical cause of ICU in the Intensive Care Unit (ICU) may be hospitalized for longer periods of time due to accompanying diseases or iatrogenic causes. This disease is called "Chronic Critical Illness" (CCI). CCI is associated with prolonged acute mechanical ventilation, but there is no definition in the literature for newborns. Pediatric CCI is estimated to be similar to adults. In the United States, the number of CCI is around 250,000, which is estimated to have doubled in the last 10 years. 50% of patients die in one year and much less than 12% recover. The estimated annual cost for the CCI in the United States is over $ 20 billion. The prevalence of Pediatric CCI in Turkey is unknown. In this study, it was aimed to investigate risk factors, mortality and cost of children with chronic critically ill and newborn patients in intensive care units in Turkey.

Conditions

Critical Illness

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Chronic Critical IIlness
• The patients who are younger than 18 years old and staying in ICU for at least 14 days.

(The patients who is newborn and stay in the intensive care unit for 30 days in addition to prematurity).

At least one of the additional criteria;

• Prolonged acute mechanical ventilation
• Tracheostomy
• Sepsis
• Severe wound (burn) or trauma
• Encephalopathy (Post resuscitation syndrome, Asphyxia, Intra-cranial hemorrhage, Metabolic disease, etc.)
• Traumatic brain injury
• Status epilepticus
• Post operative (Cardiac and noncardiac)
• Neuromuscular disease (Spinal Muscular Dystrophy, Cerebral Palsy, Muscular Dystrophy)

Exclusion Criteria

• Patients with a disease other than a chronic critical disease
• Patients older than 18 years

• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Kahramanmaras Sutcu Imam University

OTHER

Sponsor Role: collaborator

Izmir Ataturk Training and Research Hospital

OTHER

Sponsor Role: collaborator

Yuzuncu Yıl University

OTHER

Sponsor Role: lead

Responsible Party

Hilmi Demirkiran, MD

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hilmi Demirkiran, Asist.prof.

Role: PRINCIPAL_INVESTIGATOR

Department of Anethesiology and Reanimation

Locations

Yuzuncu Yil University, School of Medicine

Van, Tusba / Zeve Kampus, Turkey (Türkiye)

Countries

Turkey (Türkiye)

References

Demirkiran H, Kilic M, Tomak Y, Dalkiran T, Yurttutan S, Basaranoglu M, Tuncer O, Derme T, Tekeli AE, Bahar I, Keskin S, Oksuz H. Evaluation of the incidence, characteristics, and outcomes of pediatric chronic critical illness. PLoS One. 2021 May 28;16(5):e0248883. doi: 10.1371/journal.pone.0248883. eCollection 2021.

Reference Type: DERIVED

PMID: 34048449 (View on PubMed)

Other Identifiers

Pediatric critical illness

Identifier Type: -

Identifier Source: org_study_id