Study Using Genomic, Histologic and Radiomic Analysis to Evaluate Regional Tumor Heterogeneity in Patients Undergoing Surgery for Newly Diagnosed Glioblastoma

NCT ID: NCT03287063

Last Updated: 2025-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

6 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-05

Study Completion Date

2020-03-23

Brief Summary

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Glioblastomas (GBM) demonstrate in vivo genetic and histologic heterogeneity that can be non-invasively identified using imaging phenotypes that identify regionally distinct areas of tumor with genetic alterations that drive tumor resistance pathways. The researchers propose a unique approach to assess initial GBM heterogeneity by performing histological and genomic analysis of biopsies targeted by advanced MRI before treatment.

Detailed Description

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Conditions

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Glioblastoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Tumor Biopsy

Stereotactic biopsies will be performed prior to resection.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Suspected newly diagnosed or recurrent supratentorial glioblastoma eligible for surgical biopsy and/or resection
* Patients must be 18 years of age or older
* Study-specific informed consent approved for this purpose by the IRB of the University of Michigan

Exclusion Criteria

* Patients unable to undergo MRI
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Michigan Rogel Cancer Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michelle Kim, M.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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HUM00134165

Identifier Type: OTHER

Identifier Source: secondary_id

UMCC 2017.094

Identifier Type: -

Identifier Source: org_study_id

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