Effects of Repeated Memory Training on Memory Function and Addiction Related Processes

NCT ID: NCT03285256

Last Updated: 2020-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-05-01

Study Completion Date

2019-10-01

Brief Summary

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Prospective memory is the ability to implement an intention to the future (e.g. remember to take medication, attend a scheduled meeting), and has receive little attention in addiction. The investigators propose that prospective memory plays a critical, yet unrecognized, role in major human behavior change such as that required in addiction treatment. This study will determine the preliminary efficacy of prospective memory training in improving memory and executive functions while reducing illicit drug use in methadone patients. Participants will be randomly assigned to one of three conditions: an experimental memory training program or one of two comparator memory training programs.

Detailed Description

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Conditions

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Substance-Related Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Participants will be randomly assigned to one of three treatment conditions: an experimental memory training program or one of two comparator memory training programs.
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
Both the participant and the research assistant conducting the assessments will be blinded to group assignment.

Study Groups

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Experimental Memory Training

Experimental memory training program

Group Type EXPERIMENTAL

Experimental memory training

Intervention Type BEHAVIORAL

The experimental memory training will be implemented as a computer program that uses state-of-the-art immersive technology to simulate prospective memory in everyday life in which one must remember to carry out tasks throughout the day, while engaging in current ongoing activity. Participants are asked to imagine they have a work-at-home job (ongoing activity), which is an independent program (CogMed QM) designed to train working memory, but that they also need to remember to carry out a number of tasks throughout the day. Using a touch screen, participants will need to touch objects in the simulated environment to appropriately interact with these stimuli according to their pre-assigned tasks.

Comparator Memory Training 1

Comparator memory training program

Group Type ACTIVE_COMPARATOR

Comparator memory training 1

Intervention Type BEHAVIORAL

The first comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.

Comparator Memory Training 2

Alternative comparator memory training program

Group Type ACTIVE_COMPARATOR

Comparator memory training 2

Intervention Type BEHAVIORAL

The second comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.

Interventions

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Experimental memory training

The experimental memory training will be implemented as a computer program that uses state-of-the-art immersive technology to simulate prospective memory in everyday life in which one must remember to carry out tasks throughout the day, while engaging in current ongoing activity. Participants are asked to imagine they have a work-at-home job (ongoing activity), which is an independent program (CogMed QM) designed to train working memory, but that they also need to remember to carry out a number of tasks throughout the day. Using a touch screen, participants will need to touch objects in the simulated environment to appropriately interact with these stimuli according to their pre-assigned tasks.

Intervention Type BEHAVIORAL

Comparator memory training 1

The first comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.

Intervention Type BEHAVIORAL

Comparator memory training 2

The second comparator memory training intervention will utilize the same overall structure and immersive computer environment as the experimental memory intervention, but will not challenge the same aspects of cognition.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Age 18-55; provision of written consent
* Enrolled in a substance use treatment program
* Sex with ≥ 2 partners in the last 30 days and sex without a condom on at least one occasion in the last year

Exclusion Criteria

* Severe psychiatric conditions associated with psychosis or any unstable psychiatric condition
* History of medical, psychiatric, or neurological conditions associated with significant cognitive impairment
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johns Hopkins University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Matthew W Johnson, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Locations

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Johns Hopkins University School of Medicine, Bayview Campus

Baltimore, Maryland, United States

Site Status

Countries

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United States

Other Identifiers

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IRB00138474

Identifier Type: -

Identifier Source: org_study_id

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