Working Memory Training for Substance Dependent Individuals

NCT ID: NCT02119949

Last Updated: 2014-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-05-31

Study Completion Date

2014-06-30

Brief Summary

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Background: Substance abusers show impaired working memory (WM) functioning. Promising findings show training WM results in an improved working memory capacity (WMC) and a decrease of clinical symptoms in a range of disorders, including alcohol addiction.

Aim: To test the effect of a WM training in addition to treatment as usual (TAU) on substance use, craving, WMC, impulsivity, attention bias and psychopathology.

Design: A randomized double-blind placebo-controlled trial with a parallel group design. The WM training adapted to participants' WMC whereas the placebo training consisted of non-adaptive easy versions of these tasks.

Setting: Two departments of an addiction treatment clinic in Rotterdam, the Netherlands.

Participants: 120 inpatients diagnosed with an alcohol, cannabis or cocaine dependency who were in treatment as usual .

Measurements: Primary outcome measures: Substance use and craving. Secondary outcome measures: WMC, impulsivity, attention bias and psychopathology. Participants were assessed before and after 24 sessions of WM training as well as two months after the training.

Detailed Description

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Conditions

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Substance Dependency Addiction Anxiety Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Working memory training

Group Type EXPERIMENTAL

Working memory training

Intervention Type BEHAVIORAL

The working memory training started the day after the pre-test and included 24 sessions of 25 minutes each. Participants trained, under supervision of an experimenter, on weekdays in the clinic. The training consisted of two tasks: the Symmetry Span and the N-back Task. Participants in the experimental group executed versions of these task that adapt to their working memory capacity, to train their working memory optimally.

Placebo training

Group Type PLACEBO_COMPARATOR

Placebo training

Intervention Type BEHAVIORAL

The working memory training started the day after the pre-test and included 24 sessions of 25 minutes each. Participants trained, under supervision of an experimenter, on weekdays in the clinic. The training consisted of two tasks: the Symmetry Span and the N-back Task. Participants in the placebo group executed easy versions of these task that did not adapt to their level, to prevent training.

Interventions

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Working memory training

The working memory training started the day after the pre-test and included 24 sessions of 25 minutes each. Participants trained, under supervision of an experimenter, on weekdays in the clinic. The training consisted of two tasks: the Symmetry Span and the N-back Task. Participants in the experimental group executed versions of these task that adapt to their working memory capacity, to train their working memory optimally.

Intervention Type BEHAVIORAL

Placebo training

The working memory training started the day after the pre-test and included 24 sessions of 25 minutes each. Participants trained, under supervision of an experimenter, on weekdays in the clinic. The training consisted of two tasks: the Symmetry Span and the N-back Task. Participants in the placebo group executed easy versions of these task that did not adapt to their level, to prevent training.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Substance dependency: cocaine, cannabis or alcohol

Exclusion Criteria

* Age below 16 or above 67
* Current psychosis
* Neurological complaints
Minimum Eligible Age

16 Years

Maximum Eligible Age

67 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erasmus Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ingmar Franken

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bouman Clinic

Rotterdam, South Holland, Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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2

Identifier Type: -

Identifier Source: org_study_id

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