A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol
NCT ID: NCT04770025
Last Updated: 2025-05-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
PHASE2
75 participants
INTERVENTIONAL
2020-09-01
2026-02-28
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
High Intensity Alternating Current Stimulation as a Neuromodulation Therapy for Alcohol Use Disorder: A Pilot Study
NCT07227545
Cognitive Retraining and Brain Stimulation for Alcohol Use
NCT02045108
Neurobiological Effects of Transcranial Direct Current Stimulation Treatment in Alcohol Use Disorder
NCT04897295
Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
NCT04971681
Cerebellar Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Alcohol Use Disorder
NCT03829761
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Participants will have magnetoencephalography (MEG) scans including rest and an alcohol cue task to measure the acute effects of brain stimulation. Participants will also have MRI scans including structure and rest. The Motivational Interviewing Skill Code (MISC 2.5) and the CASAA Application for Coding Treatment Interactions (CACTI) will be used to assess counselor and participant speech in the recorded MI sessions and to ensure that sessions comply with the principles of MI.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
MI with tACS
Motivational interviewing with concurrent active stimulation
High-density transcranial alternating current stimulation
High-density electrode configuration with transcranial alternating current stimulation in the beta (15-40Hz) frequency range
Motivational interviewing
Motivational interviewing session focused on alcohol use, approximately 30 minutes in length
MI with sham
Motivational interviewing with concurrent sham stimulation
Sham stimulation
High-density electrode configuration with sham stimulation
Motivational interviewing
Motivational interviewing session focused on alcohol use, approximately 30 minutes in length
MI-only
Motivational interviewing only, delayed treatment control
Motivational interviewing
Motivational interviewing session focused on alcohol use, approximately 30 minutes in length
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
High-density transcranial alternating current stimulation
High-density electrode configuration with transcranial alternating current stimulation in the beta (15-40Hz) frequency range
Sham stimulation
High-density electrode configuration with sham stimulation
Motivational interviewing
Motivational interviewing session focused on alcohol use, approximately 30 minutes in length
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Right-handed
* Age 21-60 years
* AUDIT score indicating risky drinking
Exclusion Criteria
* Currently engaged in treatment for alcohol use disorder
* Receiving treatment for alcohol use disorder within the prior 12 months
* History of brain injury or neurological diagnosis
* Evidence of current psychosis
* Past-year substance use disorder other than alcohol, marijuana, or nicotine
* Current or history of severe alcohol withdrawal
* MRI/tACS contraindications including pregnancy
* Impaired hearing (psychotherapy using American Sign Language is not possible within the scope of the proposed study)
* Insufficient corrected visual acuity to complete the assessment instruments
* Unable to read/speak English fluently
* Unable to provide valid informed consent
21 Years
60 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute of General Medical Sciences (NIGMS)
NIH
The Mind Research Network
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
The Mind Research Network
Albuquerque, New Mexico, United States
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Provided Documents
Download supplemental materials such as informed consent forms, study protocols, or participant manuals.
Document Type: Informed Consent Form: Informed Consent
Document Type: Informed Consent Form: Informed Consent - Phase I online-only
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
20-010
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.