Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
NCT ID: NCT03283072
Last Updated: 2023-08-21
Study Results
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View full resultsBasic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2017-09-18
2020-07-06
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
DOUBLE
Study Groups
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Sequence 1
Intervention 1: 15 bouts of 2mins:1min hypoxia:hyperoxia Intervention 2: 15 bouts of 1mins:1min hypoxia:hyperoxia Intervention 3: 8 bouts of 2mins:1min hypoxia:hyperoxia 15 bouts of 1min:1min normoxia (sham)
Intervention 1
15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 2
15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 3
8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 4 (sham)
15 bouts of 1min:1min normoxia
Sequence 2
Intervention 2: 15 bouts of 1mins:1min hypoxia:hyperoxia Intervention 3: 8 bouts of 2mins:1min hypoxia:hyperoxia 15 bouts of 1min:1min normoxia (sham) Intervention 1: 15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 1
15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 2
15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 3
8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 4 (sham)
15 bouts of 1min:1min normoxia
Sequence 3
Intervention 3: 8 bouts of 2mins:1min hypoxia:hyperoxia 15 bouts of 1min:1min normoxia (sham) Intervention 1: 15 bouts of 2mins:1min hypoxia:hyperoxia Intervention 2: 15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 1
15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 2
15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 3
8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 4 (sham)
15 bouts of 1min:1min normoxia
Sequence 4
15 bouts of 1min:1min normoxia (sham) Intervention 1: 15 bouts of 2mins:1min hypoxia:hyperoxia Intervention 2: 15 bouts of 1mins:1min hypoxia:hyperoxia Intervention 3: 8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 1
15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 2
15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 3
8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 4 (sham)
15 bouts of 1min:1min normoxia
Interventions
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Intervention 1
15 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 2
15 bouts of 1mins:1min hypoxia:hyperoxia
Intervention 3
8 bouts of 2mins:1min hypoxia:hyperoxia
Intervention 4 (sham)
15 bouts of 1min:1min normoxia
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Diagnosis of neuromuscular disease
* Diagnosis of any neurological disease
* Presence of concurrent medical illness including infection, fractures
* Diagnosis of obstructive sleep apnea
* Diagnosis of obstructive/restrictive lung disease
* Diagnosis of exercise induced asthma
* FEV1/FVC\<80% and/or FVC\<80% of predicted value indicating airway obstruction
* Subjects on prednisolone therapy or selective serotonin reuptake inhibitor (SSRI) therapy will be excluded from the study as these pharmacological agents are known to amplify the effects of IH\[22, 23\]
* Diagnosis of epilepsy or history of seizures and attention deficit disorders
* Pregnancy
* Diabetes
* History of coagulation disorders
* History of chronic pain
* Body mass index(BMI)\> 35kg/m2
* Subjects on prescription medicines such as beta blockers and other drugs that are prescribed in any of the exclusionary disorders listed above.
18 Years
40 Years
ALL
Yes
Sponsors
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University of Florida
OTHER
Responsible Party
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Principal Investigators
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Mark D Bishop, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
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Unversity of Florida
Gainesville, Florida, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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IRB201700637
Identifier Type: -
Identifier Source: org_study_id
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