Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury
NCT ID: NCT03263325
Last Updated: 2023-02-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
250 participants
OBSERVATIONAL
2017-10-25
2023-08-01
Brief Summary
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A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury.
This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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AKI Group
Patients developing AKI after surgery
Discarded urine sample
Collection of discarded urine during surgery and following surgery
No AKI Group
Patients who do not develop AKI after surgery
Discarded urine sample
Collection of discarded urine during surgery and following surgery
Interventions
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Discarded urine sample
Collection of discarded urine during surgery and following surgery
Eligibility Criteria
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Inclusion Criteria
* scheduled for cardiac surgery
Exclusion Criteria
8 Years
ALL
No
Sponsors
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Boston Children's Hospital
OTHER
Responsible Party
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Douglas Atkinson
Cardiac Anesthesiologist
Principal Investigators
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Douglas Atkinson, MD
Role: PRINCIPAL_INVESTIGATOR
Boston Children's Hospital
Locations
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Boston Children's Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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IRB-P00025852
Identifier Type: -
Identifier Source: org_study_id
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