Normal Parameters of Cranial Vessels Using Cranial Vascular Duplex Among Egyptian Population

NCT ID: NCT03252652

Last Updated: 2017-08-17

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-10-31
• Study Completion Date: 2019-10-31

Brief Summary

the study will be carried out to standardize normal parameters of vascular duplex ultrasound of the cranial vessels in the Egyptian population.

Detailed Description

Atherosclerosis is a major cause of ischemic stroke and a significant proportion of strokes are thromboembolic in nature, arising from atherosclerotic plaques. Several studies have reported racial differences in the severity and distribution of carotid atherosclerosis. In the United States and Western communities, Extra-cranial carotid artery disease was estimated to be responsible for 20-30% of strokes. Little is known about the prevalence and distribution of carotid disease among the populations in the developing countries.

Vascular duplex ultrasound is a useful, cheap and available diagnostic tool for assessing cranial vascular disease. Duplex ultrasound can be highly reliable with proper technique, without the risk of radiation in other imaging modalities, is well tolerated by all patients including those who are claustrophobic in MRI machines, and has much less risks compared to conventional angiography studies.

Although vascular duplex has been used for years yet there is little researches had been done on normal population in the developing countries to collect results and compare it to the parameters that was collected and reviewed in the western developed populations.

The parameters that would be used in this study include both the data collected by static and dynamic duplex scan which are the intimal-medial thickness, the vessels' diameter, peak flow velocity and peak flow volume both systolic and diastolic for either extra- or intra-cranial vessels.

Conditions

Atherosclerosis; Atheroma of Cerebral Arteries; Atheroma; Carotid Artery; Atheroma; Cerebral

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Interventions

vascular duplex ultrasound imaging

Duplex ultrasound is a non-invasive evaluation of blood flow through cranial arteries and veins.

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• Normal subjects between 20-40 years

Exclusion Criteria

• Diabetic patients, hypertensive patients, any evidence of vascular disease either peripheral or central, subjects refusing to participate

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mostafa Mohammed Hamdy Ghazally

principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Mostafa H Ghazally, MBChB

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Central Contacts

Tarek A Rageh, PHD

Role: CONTACT

Tarek_rageh@hotmail.com

+0201223849203

Khaled O Abosheira, PHD

Role: CONTACT

+0201003012229

References

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Reference Type: BACKGROUND

PMID: 15470212 (View on PubMed)

Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, Glahn J, Brandt T, Hacke W, Diener HC. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke. 2001 Nov;32(11):2559-66. doi: 10.1161/hs1101.098524.

Reference Type: BACKGROUND

PMID: 11692017 (View on PubMed)

Timsit SG, Sacco RL, Mohr JP, Foulkes MA, Tatemichi TK, Wolf PA, Price TR, Hier DB. Early clinical differentiation of cerebral infarction from severe atherosclerotic stenosis and cardioembolism. Stroke. 1992 Apr;23(4):486-91. doi: 10.1161/01.str.23.4.486.

Reference Type: BACKGROUND

PMID: 1561677 (View on PubMed)

Svicero DJ, Doiche DP, Mamprim MJ, Heckler MC, Amorim RM. Ultrasound evaluation of common carotid artery blood flow in the Labrador retriever. BMC Vet Res. 2013 Oct 7;9:195. doi: 10.1186/1746-6148-9-195.

Reference Type: BACKGROUND

PMID: 24094043 (View on PubMed)

Other Identifiers

SNPCUETCDE

Identifier Type: -

Identifier Source: org_study_id