Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

NCT ID: NCT00424957

Last Updated: 2009-02-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 18 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-11-30
• Study Completion Date: 2008-10-31

Brief Summary

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Conditions

Cirrhosis; Hepatic Encephalopathy

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
• 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
• 6 healthy subjects age and sex matched

Exclusion Criteria

• Neurological and/or psychiatric condition,
• Non-treated diabetes,
• Pregnancy/breast-feeding

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Aarhus

OTHER

Sponsor Role: lead

Responsible Party

PET Center, Aarhus University Hospital

Principal Investigators

Susanne Keiding, MD

Role: STUDY_CHAIR

PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

Locations

PET Centre, Aarhus University Hospital

Aarhus, , Denmark

Countries

Denmark

References

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. doi: 10.1016/j.neuint.2005.04.002.

Reference Type: BACKGROUND

PMID: 15921824 (View on PubMed)

Other Identifiers

20060120

Identifier Type: -

Identifier Source: org_study_id