Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study
NCT ID: NCT02357550
Last Updated: 2016-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
9 participants
INTERVENTIONAL
2015-03-31
2016-01-31
Brief Summary
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Hypotheses
1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
3. Altered oxygen consumption during hyperketonemia in healthy subjects.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Control
Saline infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
placebo
Saline infusion.
Hyperketonaemia
Ketone infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
ketone
3-OHB is infused intravenously.
Interventions
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ketone
3-OHB is infused intravenously.
placebo
Saline infusion.
Eligibility Criteria
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Inclusion Criteria
* BMI 20-30 kg/m2
Exclusion Criteria
* alcohol abuse
* severe comorbidity
* blood donation 6 month prior
* claustrophobia
50 Years
70 Years
ALL
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Mads Svart, MD
Role: PRINCIPAL_INVESTIGATOR
Aarhus University / Aarhus University Hospital
Locations
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Aarhus University Hospital
Aarhus, , Denmark
Countries
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References
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Lauritzen ES, Svart MV, Voss T, Moller N, Bjerre M. Impact of Acutely Increased Endogenous- and Exogenous Ketone Bodies on FGF21 Levels in Humans. Endocr Res. 2021 Feb;46(1):20-27. doi: 10.1080/07435800.2020.1831015. Epub 2020 Oct 19.
Lauritsen KM, Sondergaard E, Svart M, Moller N, Gormsen LC. Ketone Body Infusion Increases Circulating Erythropoietin and Bone Marrow Glucose Uptake. Diabetes Care. 2018 Dec;41(12):e152-e154. doi: 10.2337/dc18-1421. Epub 2018 Oct 16. No abstract available.
Other Identifiers
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RM-1-10-72-106-14
Identifier Type: -
Identifier Source: org_study_id
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