Causes of Goiter in Children Attending Assiut University Children Hospital

NCT ID: NCT03202160

Last Updated: 2017-06-28

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-04-15
• Study Completion Date: 2019-09-15

Brief Summary

Thyroid disorders are one of the most common endocrine problems in children and adolescents. Diagnostic considerations can be approached from the perspective of the goiter.A goiter, or thyromegaly, is an enlargement of the thyroid gland.Persons with enlarged thyroids can have normal function of the gland (euthyroidism), thyroid deficiency (hypothyroidism), or overproduction of the hormones (hyperthyroidism).

Detailed Description

Congenital goiter most commonly occurs in neonates born to mothers with known thyroid disease especially Graves' disease. Other causes of congenital goitrous hypothyroidism are thyroid dyshormonogenesis, endemic iodine deficiency and maternal goitrogen ingestion or iodine excess (expectorants, povidone iodine).

The most common causes of euthyroid goiter in childhood are chronic lymphocytic thyroiditis and a colloid goiter (simple goiter). Thyroid enlargement that is not caused by inflammatory, infectious or neoplastic causes is termed a colloid goiter, also.

Chronic lymphocytic thyroiditis , also known as Hashimoto thyroiditis, is an autoimmune, inflammatory process that causes up to 55% to 65% of all euthyroid goiters, and almost all cases of thyroiditis in childhood and adolescence. A large North American prevalence study showed that as many as 1.2% of children aged 11 to18 years have chronic lymphocytic thyroiditis, as defined by an enlarged thyroid gland and detectable serum thyroid antibodies.

Thyroid nodules are relatively common in adolescents; these nodules are usually asymptomatic and often discovered incidentally, but they raise the fear of cancer. A multi-nodular goiter is almost invariably caused by Hashimoto's thyroiditis and it carries a good prognosis. The asymptomatic, solitary thyroid nodule is a thyroid adenoma, thyroid carcinoma or a thyroid cyst. Thyroid carcinoma occurs in approximately one per one million persons/year in the first-two decades of life.

No reported data are found as regard of causes of goiter in children in our locality.

Conditions

Goiter

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Children of both sexes of ages since birth up to 18 years old who are presented by goiter.

Exclusion Criteria

• Any patient with neck swelling other than goiter.
• Refusal of participation.

• Minimum Eligible Age: 1 Day
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

MAAta

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hanaa A Mohammed, MD

Role: STUDY_CHAIR

Assiut University

Central Contacts

Hanaa A Mohammed, MD

Role: CONTACT

hae50@hotmail.com

00201120096055 ext. Assiut

Eman A Abdel-Raoof, MD

Role: CONTACT

emanaskar@hotmail.com

00201099696173 ext. Assiut

References

Muirhead S. Diagnostic approach to goitre in children. Paediatr Child Health. 2001 Apr;6(4):195-9. doi: 10.1093/pch/6.4.195.

Reference Type: BACKGROUND

PMID: 20084235 (View on PubMed)

Other Identifiers

CGCA

Identifier Type: -

Identifier Source: org_study_id